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Clinical Trial Summary

Aneurysmal subarachnoid hemorrhage (aSAH) has a high incidence of mortality and significant morbidity, with mortality exceeding 30% in the first two days.The initial injury is related to increasing intracranial pressure, cerebral edema, and neuronal injuries associated with the release of iron. Iron has been shown to increase the incidence of cerebral edema, ischemia, and formation of hydrocephalus. Deferoxamine mesylate (DFO), a hydrophilic chelator, creates a stable complex with free iron thus preventing the formation of iron related free radicals. This trial will evaluate the safety and efficacy of clinical deferoxamine for the treatment of aSAH for patients that are admitted to the hospital at the University of Michigan or Peking University Health Science Center. Eligible participants will be enrolled and randomized to 1 of 2 doses of Deferoxamine or placebo (saline). Information regarding the patients will be collected and followed for up to 6 months post discharge.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04566991
Study type Interventional
Source University of Michigan
Contact Sravanthi Koduri
Phone 734-647-7960
Email skoduri@med.umich.edu
Status Recruiting
Phase Phase 2
Start date March 20, 2022
Completion date October 2025

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