AAB-001 (Bapineuzumab) Open-Label, Long-Term Extension Study in Patients With Mild to Moderate Alzheimer's Disease

Alzheimer's Disease Clinical Trial

Official title:

A Phase II, Multicenter, Open-Label, Long-Term Treatment Study to Determine the Safety, Tolerability, and Efficacy of Bapineuzumab (AAB-001) in Patients With Alzheimer's Disease Who Participated in Study AAB-001-201 or AAB-001-102

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00606476
• Other study ID #: AAB-001-251
• Status: Terminated
• Phase: Phase 2
• First received: January 11, 2008
• Last updated: October 30, 2013
• Start date: December 2006
• Est. completion date: September 2012

Study information

• Verified date: August 2012
• Source: JANSSEN Alzheimer Immunotherapy Research & Development, LLC
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

This is a multicenter, open-label, long-term extension study in male and female patients with mild to moderate Alzheimer's Disease (AD) who must have completed one of the following studies: AAB-001-201 or AAB-001-102. All patients enrolled in Study AAB-001-251 will receive infusions of AAB-001 (bapineuzumab), including patients randomized to placebo in Study 201 and 102. Approximately 30 study sites in the US will be involved. Each patient's participation may vary from 3 months up to 84 months depending on the date of enrollment in this study.

AAB-001 (bapineuzumab) is a humanized monoclonal antibody, which binds to and potentially clears beta amyloid peptide, and is designed to provide antibodies to beta amyloid directly to the patient.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 194
• Est. completion date: September 2012
• Est. primary completion date: September 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

A subject must meet ALL of the following criteria to be considered for enrollment into this study:

1. Signed and dated written informed consent obtained from the subject and/or the subject's caregiver in accordance with the local regulations.

2. Subjects must have completed Study 201 Visit 22 (Week 78), or Study 102 Visit 11 (Week 16).

3. Magnetic resonance imaging scan of sufficient quality for the Radiologist to evaluate subject safety from Study 201 Visit 21 (Week 71), or Study 251 Screening Visit for subjects from Study 102.

4. Lives at home with appropriate caregiver capable of accompanying the subject on all clinic visits, or community dwelling with caregiver capable of accompanying the subject on all clinic visits and visiting with the subject approximately five times per week for the duration of the study.

5. In the opinion of the investigator, the subject and the caregiver will be compliant.

Exclusion Criteria:

ANY one of the following will exclude a subject from being enrolled into the study:

1. Significant neurological disease other than AD that may affect cognition.

2. Screening visit brain MRI scan (ie, Study 201 Visit 21 (Week 71), or for Study 102, the Study 251 Screening Visit) indicative of any other significant abnormality including but not limited to multiple microhemorrhages or evidence of a single prior hemorrhage >1 cm3, multiple lacunar infarcts or evidence of a single prior infarct >1 cm3, evidence of a cerebral contusion, encephalomalacia, arachnoid cysts, or brain tumors (eg, meningioma) unless approved by the medical monitor.

3. Current presence of a clinically significant major psychiatric disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) or any clinically significant symptom that could affect the subject's ability to participate in the study.

4. Current clinically significant systemic illness that is likely to result in deterioration of the subject's condition or affect the subject's safety during the study.

5. History of clinically evident stroke or history of clinically significant carotid or vertebrobasilar stenosis or plaque.

6. History of seizures, excluding febrile seizures in childhood.

7. Weight greater than 120 kg (264 lbs).

8. History or evidence of any clinically significant autoimmune disease or disorder of the immune system.

9. Clinically significant infection within the last 30 days (eg, chronic persistent or acute infection).

10. Treatment with immunosuppressive medications (eg, systemic corticosteroids) within the last 90 days (topical and nasal corticosteroids and inhaled corticosteroids for asthma are permitted) or chemotherapeutic agents for malignancy within the last three years.

11. Myocardial infarction within the last two years.

12. History of cancer within the last five years, with the exception of basal cell carcinoma, and nonmetastatic squamous cell carcinoma of the skin.

13. Other clinically significant abnormality on screening (ie, Study 201 Visit 22 [Week 78], or Study 102 Visit 11 [Week 16]) physical, neurological, laboratory, or ECG examination (eg, atrial fibrillation) that could compromise the study or be detrimental to the subject.

14. Hemoglobin less than 11 g/dL at screening (ie, Study 201 Visit 22 [Week 78], or Study 102 Visit 11 [Week16]).

15. Smoking more than 20 cigarettes per day.

16. History of alcohol or drug dependence or abuse within the last two years.

17. Current use of anticonvulsant for seizures, anti-Parkinson's, anticoagulant (excluding the use of aspirin 325 mg/day or less), or narcotic medications.

18. Any prior experimental treatment with AN1792 or other experimental immunotherapeutic or vaccine for AD (other than bapineuzumab).

19. Any known hypersensitivity to any of the excipients contained in the study drug formulation.

20. Women of childbearing potential.

21. Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, cerebrospinal fluid (CSF) shunts, metal fragments or foreign objects in the eyes, skin, or body that would contraindicate a brain MRI scan (unless otherwise approved by the Sponsor and/or its designees).

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease

Intervention

Drug:
• Bapineuzumab (AAB-001)
IV q13w

Locations

Country	Name	City	State
United States	Janssen AI Investigational Site	Ann Arbor	Michigan
United States	Janssen AI Investigational Site	Bennington	Vermont
United States	Janssen AI Investigational Site	Boston	Massachusetts
United States	Janssen AI Investigational Site	Chicago	Illinois
United States	Janssen AI Investigational Site	Dallas	Texas
United States	Janssen AI Investigational Site	Delray Beach	Florida
United States	Janssen AI Investigational Site	Durham	North Carolina
United States	Janssen AI Investigational Site	Eatontown	New Jersey
United States	Janssen AI Investigational Site	Encino	California
United States	Janssen AI Investigational Site	Houstan	Texas
United States	Janssen AI Investigational Site	Indianapolis	Indiana
United States	Janssen AI Investigational Site	Irvine	California
United States	Janssen AI Investigational Site	Jacksonville	Florida
United States	Janssen AI Investigational Site	La Jolla	California
United States	Janssen AI Investigational Site	Los Alamitos	California
United States	Janssen AI Investigational Site	New Haven	Connecticut
United States	Janssen AI Investigational Site	New York City	New York
United States	Janssen AI Investigational Site	Peoria	Arizona
United States	Janssen AI Investigational Site	PIttsburgh	Pennsylvania
United States	Janssen AI Investigational Site	Portland	Oregon
United States	Janssen AI Investigational Site	Providence	Rhode Island
United States	Janssen AI Investigational Site	Rochester	New York
United States	Janssen AI Investigational Site	Rochester	Minnesota
United States	Janssen AI Investigational Site	Sacramento	California
United States	Janssen AI Investigational Site	San Francisco	California
United States	Janssen AI Investigational Site	Seattle	Washington
United States	Janssen AI Investigational Site	St. Louis	Missouri
United States	Janssen AI Investigational Site	Sun City	Arizona
United States	Janssen AI Investigational Site	Washington	District of Columbia

Sponsors (1)

Lead Sponsor	Collaborator
JANSSEN Alzheimer Immunotherapy Research & Development, LLC

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To assess the safety and tolerability of long-term treatment of bapineuzumab in subjects with AD.	The incidence and severity of treatment-emergent adverse events (TEAEs); Clinically important changes in safety assessment results (including, as appropriate, vital signs, weight, clinical laboratory tests, electrocardiograms [ECGs], brain magnetic resonance imaging [MRIs], physical and neurological examinations, and infusion site assessments).	3-84 months	No
Secondary	To evaluate the efficacy of long-term treatment of bapineuzumab in subjects with AD.	Change from Visit 2 (Pre-Day 1) and Visit 22 (Week 78) of Study AAB-001-201 for the following scales: Alzheimer's Disease Assessment Scale - Cognitive subscale (ADAS-Cog); Disability Assessment for Dementia (DAD); Mini Mental State Examination (MMSE); Change from Study AAB-001-251Visit 1 (Day 1) for the following scales: Dependence Scale; Resource Utilization in Dementia (RUD) Lite; Change from Study 251 Screening Visit for the following scales for subjects entering from Study AAB-001-102 (US): ADAS-Cog; DAD; MMSE	3-84 months	No