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Clinical Trial Summary

This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo. During the scan, the investigators will assess reward.

Clinical Trial Description

The study will employ a crossover design. The study will use the monetary incentive delay task during functional MRI to assess reward. This task presents participants with cues indicating whether they are playing to win $5, win $0, or to avoid losing $5. This task has been well-validated to elicit activation in a key reward response area of the brain called the ventral striatum. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT04854551
Study type Interventional
Source University of Colorado, Denver
Contact Joshua Gowin, PhD
Phone 3037243769
Email [email protected]
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date May 1, 2021
Completion date April 30, 2022

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