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Clinical Trial Summary

Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread success in preventing this postoperative decline in renal function. Nitric oxide is an intricate regulator of acute inflammation and coagulation and is a potent vasodilator. The investigators hypothesize that nitric oxide, administered during cardiopulmonary bypass (CPB), may reduce the incidence of AKI.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04216927
Study type Interventional
Source Children's Hospital Medical Center, Cincinnati
Contact David S Cooepr, MD
Phone 5138035448
Email David.Cooper@cchmc.org
Status Recruiting
Phase Phase 3
Start date January 10, 2023
Completion date June 1, 2025

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