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Continuous Negative Abdominal Pressure in ARDS (CNAP in ARDS) — CNAP in ARDS  

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Continuous Negative Abdominal Pressure in ARDS (CNAP in ARDS)

Clinical Trial Summary

The aim is to test a device for applying continuous negative abdominal pressure in patients with ARDS

Clinical Trial Description

Adult respiratory distress syndrome (ARDS) is a serious pulmonary disease affecting adults and children. It has a high mortality and there is no specific therapy. The mortality is high (approx. 40% in severe cases) and this has not changed in the last 20 years. Mechanical ventilation is the mainstay of management, and this assists the patient by increasing oxygenation and removal of carbon dioxide. Despite optimizing tidal volume, driving pressure and positive end-expiratory pressure (PEEP), patients with ARDS develop large areas of atelectasis and poor oxygenation. There are few additional ventilator approaches that have proven to be useful in preventing this type of injury. A major aim of ventilator support is recruitment of atelectatic (i.e. de-airated) lung, but while this is supported by excellent rational and laboratory data, the conventional clinical approaches have not been associated with a demonstrable improvement in patient outcome. Most atelectasis in ARDS occurs in the dorsal (dependant, lower-most) lung regions, and these are near the diaphragm. The main ways to recruit lung are to increase the airway distending pressure (but this over-expands and damages the already-aerated lung regions); or, to turn the patient into the prone position (but clinicians are reluctant to utilize this approach - despite evidence that it may increase survival). Continuous Negative Abdominal Pressure (CNAP) aims to selectively recruit basal atelectatic areas of lung, while enabling the patient to remain in the supine (usual) position. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03425318
Study type Interventional
Source The Hospital for Sick Children
Contact Doreen Engelberts
Phone 416 813 8891
Email doreen.engelberts@sickkids.ca
Status Recruiting
Phase N/A
Start date January 4, 2019
Completion date December 2024
View Details
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