Acute Lymphoblastic Leukemia Clinical Trial
Official title:
Dependence Receptors in Childhood Acute Leukemia
Acute leukaemias (AL) are the first cause of cancer in children, with a majority of B acute
lymphoblastic leukemia (ALL). Some of the processes causing leukemogenesis are already
identified and well characterized in some AL subtypes such as translocation t (12; 21) of
good prognosis in ALL. However, translocations are not sufficient to explain all the
different processes of leukemogenesis, and other processes such as genetic / epigenetic
mutations leading to oncogene activation / inhibition of tumor suppressor genes are the
object research. Among the latter, mutations in tumor suppressor genes such as DCC (Deleted
in Colorectal Cancer) have recently been identified in solid cancers, such as in hemopathies.
This gene was subsequently characterized as encoding a "dependence receptor" specifically
binding to its Netrin-1 ligand.
Dependence receptors (RDs) are transmembrane receptors that cause cell death in the absence
of their ligand. RD decreases tumor progression and overexpression of their ligands is
observed in many cancers, such as B lymphomatous hemopathies in adults. Inhibition of the
RD-ligand interaction constitutes a new and original therapeutic target in oncology.
The aim of this study is to investigate whether RDs, in particular DCC, are expressed in
acute leukemia cells at the time of diagnosis or relapse in patients aged 1 to 18 years, and
then in these patients at the time of the remission balance. This research will be both
qualitative and quantitative.
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