Acute Lung Injury Clinical Trial
Official title:
Effects of PEEP in Brain Injury Patients
The hypothesis is that brain injury patients have alterations of the respiratory system related to intraabdominal pressure. Furthermore application of moderate levels of PEEP may improve respiratory function in these patients.
We investigate the mechanical properties of the respiratory system, partitioned into its
lung and chest wall components, the functional residual capacity, the gas-exchange and
alveolar recruitment in brain injured patients.
The measurements will be performed under sedation at different levels of PEEP. The following
groups will be included: a) control patients withot lung injury and brain injury; b) brain
injured patients without lung injury within the first 72 hours; c) brain injured patients
without lung injury after 72 hours; d) brain injured patients with lung injury. Brain injury
was defined as primary or secondary. Respiratory functional data will be related to
intra-abdominal pressure.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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