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Furosemide Stress Test to Predict Successful Liberation From RRT — FST-RRT  

Acute Kidney Injury Clinical Trial

Official title:
Evaluation of the Furosemide Stress Test to Predict Successful Liberation From Renal Replacement Therapy in Critically Ill Patients

Clinical Trial Summary

The proposed study will evaluate if a standardised dose of furosemide administered in the 12 hours after RRT liberation can predict successful liberation in critically ill patients. The dose that will be administered is in accordance with the prescribing information.

Clinical Trial Description

Response to furosemide administration is commonly used in clinical practice to assess a patient's potential for RRT liberation. However, this administration is not standardized and practices varies greatly. Rapid recognition of unsuccessful RRT liberation is crucial to avoid further complications such as fluid overload or acid-base and electrolyte disorders. The FST corresponds to the intravenous administration of 1 mg/kg (1.5 mg/kg in previously exposed patients) of furosemide and the assessment of resulting diuresis in the following two hours. FST is able to predict progression from AKI stage I and II to stage III with a high sensitivity (87.1%) and specificity (84.1%), area under the ROC curve 0.87. However, the ability of FST to predict RRT liberation has never been formally assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05612490
Study type Observational
Source Centre Hospitalier Universitaire Vaudois
Contact Antoine schneider, MD PhD
Phone +41795561902
Email antoine.scheider@chuv.ch
Status Recruiting
Phase
Start date January 17, 2023
Completion date July 31, 2025
View Details
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