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DCS Versus DES for One-month DAPT in Patients With ACS: ONE-PASS Trial — ONE-PASS  

Acute Coronary Syndrome Clinical Trial

Official title:
Drug-Coated Stent Versus Drug-Eluting Stent for One-month Dual-antiplatelet Therapy in Patients With Acute Coronary Syndrome: ONE-PASS Trial

Clinical Trial Summary

To test whether the polymer-free drug-coated stent (DCS) BioFreedom is noninferior to the biodegradable polymer drug-eluting stent (DES) Ultimaster in terms of 1-year patient-oriented composite endpoint (POCE, composite of all-cause mortality, any MI, or any revascularization) in a setting of 1-month dual-antiplatelet therapy (DAPT) strategy (1-month DAPT followed ticagrelor monotherapy) after acute coronary syndrome.

Clinical Trial Description

This trial is an open-label, randomized, multi-center study. Patients with ACS requiring percutaneous coronary intervention will be randomized with a 1:1 ratio either of DCS group or DES group. After the index procedure, DAPT (100 mg aspirin qd and 90 mg ticagrelor bid) will be given for 1 month. After this, ticagrelor monotherapy will be maintained for 11 months. Clinical events will be evaluated within 12 months after randomization. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05305482
Study type Interventional
Source Yonsei University
Contact Chul-Min Ahn
Phone +82-2-2228-8532
Email drcello@yuhs.ac
Status Recruiting
Phase N/A
Start date August 10, 2022
Completion date May 2027
View Details
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