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Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans

Driving Under the Influence Clinical Trial

Official title:
Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans

Clinical Trial Summary

Alcohol is abused commonly, but there is no remedy for alcohol intoxication. This project is looking at the substance iomazenil and its effect on alcohol intoxication and alcohol's effects on driving using a driving simulator.

Clinical Trial Description

Alcohol is abused commonly, but there is no antidote for alcohol intoxication the way naltrexone or naloxone is an antidote for opioids. A medication that has the potential to block alcohol actions in the Central Nervous System could act as a unique medication in the treatment of alcohol intoxication and alcoholism. This project is evaluating the benzodiazepine partial inverse agonist, iomazenil, as an agent that could reverse alcohol's effects on subjective intoxication, alcohol's effects on driving using a driving simulator and on measures of electrophysiology in the laboratory in healthy subjects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01590277
Study type Interventional
Source VA Office of Research and Development
Contact
Status Active, not recruiting
Phase Phase 1
Start date December 14, 2012
Completion date June 30, 2023
View Details
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