Efficacy of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild to Moderate Acne Vulgaris

Acne Vulgaris Clinical Trial

Official title:

Efficacy of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild to Moderate Acne Vulgaris

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05712837
• Other study ID #: CMHAtd-ETH-15-Derm-22
• Status: Completed
• Phase: N/A
• Start date: June 1, 2022
• Est. completion date: November 30, 2022

Study information

• Verified date: January 2023
• Source: Combined Military Hospital Abbottabad
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To compare the efficacy of 25% trichloroacetic acid peel versus 30% salicylic acid peel in mild to moderate acne vulgaris.

Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from 01 Jun 2022 to 30th Nov, 2022.

Methodology: A total of 60 patients presented with mild or moderate acne vulgaris were randomized into two groups comprising 30 patients in each group and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Patients in Group A were treated with 25% TCA peel whereas patients in Group B were treated with 30% SA peel. At the end of therapy after 12 weeks, evaluation of active acne was done by individual lesion counts (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: November 30, 2022
• Est. primary completion date: November 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 13 Years to 22 Years

Eligibility

Inclusion Criteria:

• Patients with mild or moderate facial acne vulgaris presented in dermatology opd

Exclusion Criteria:

• Patients with grade III or IV acne vulgaris

• patients taking any acne medications or had taken oral or topical medications in the past 4 weeks

• pregnant female patients or nursing a baby

• patients with known hypersensitivity to the formulations used in the study or a history of photosensitivity

• hypertrophic scars, keloidal tendency, active or recurrent herpes simplex infection

• active dermatosis

• unrealistic expectations

Related Conditions & MeSH terms

• Acne Vulgaris

Intervention

Drug:
• 25% TRICHLOROACETIC ACID
Patients of group A were treated with 25% TCA peel and patients at 2-week intervals for a total of 12 weeks. Clinical evaluation was done at the end of therapy after 12-weeks of treatment.
• 30% salicylic acid
Patients of group B were treated with 30 % salicylic acid peel and patients at 2 weeks interval for a total of 12 weeks.clinical evaluation was done at the end of therapy after 12 weeks of treatment

Locations

Country	Name	City	State
Pakistan	Cmh abbottabad	Abbottabad	Kpk

Sponsors (1)

Lead Sponsor	Collaborator
Combined Military Hospital Abbottabad

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effectiveness of 25 % trichloroacetic acid peel versus 30 % salicylic acid peel in the treatment of mild to moderate acne vulgaris	Michaelson acne scores (MAS) Michaelson acne scores (MAS) was used to measure the effectiveness of both peels	12 weeks