Abnormality in Synovial Tissue Clinical Trial
Official title:
Examination of Biopsies From Healthy Knee Joints for the Use of Research Activities in Inflammatory Joint Diseases
The purpose of the project is to examine what kind of molecular mechanism which causes inflammatory joint diseases. This examination is carried out by a collection and analysis of synovial tissues for patients without inflammatory joint diseases compared to the experienced equivalent biopsies from patients with inflammatory joint diseases.
Arthritis is caused by autoimmune disease in the cells and pathogenesis of the tissue. This
autoimmune inflammation is very often a chronic disease which causes irreversible articular
damage. Rheumatoid arthritis is very often a painful and disabling disease if the treatment
turns out to be ineffectual. Several of the available remedies can not treat the disease
totally but only keep the patients in check.
The biological mechanisms which cause an autoimmune inflammatory articular disease have not
been proved scientifically yet. Under normal conditions, the immune system adapts easily in
order to protect the body against pathogenic bacteria and virus without causing damage on
the body's own cells. Autoimmune inflammatory diseases displace this balance in a way so
that the immune system can not distinguish between "self" and "non-self". Different kinds of
cells are involved in this chronic inflammation in the joints. Majority of these cells
belong to the heart of the immune response, for example T-lymphocytes, B-lymphocytes,
macrophages, dendrites and granulocytes. However, other cells are also involved, for example
synovial fibroblasts and endothelium.
It is very important to understand the interaction of these cells in order to develop new
medicinal products for inflammatory articular diseases. The big challenge for conduction
research in inflammatory articular diseases is to achieve more evidence-based knowledge of
the synovial tissue from the patients and the control group.
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Observational Model: Cohort, Time Perspective: Retrospective