Wound Healing Clinical Trial
Official title:
Effect of Supplementation With b- Hydroxy Methyl Butyrate and Glutamine in Wound Healing Histology in Type 2 Diabetes and Controls Bloody Areas
A randomized controlled clinical trial in two groups of supplementation with HMB and glutamine. Each group consist in 25 patients with bloody areas, one group will receive and intervention with HMB and Glutamine and the other will receive a placebo with calcium caseinate.
A fundamental part of the integral management of wound healing in patients with bloody areas
is nutrition, since it involves biochemical events that depend on the substrates it provides.
Wound healing is a phase that demands higher needs of energy-protein than the requirement.
Problem statement: Poor nutrition decreases, through specific phases, normal processes that
allow the progression of wound healing. Nutrient deficiencies can have negative effects on
wound healing by prolonging the inflammatory phase, decreasing fibroblast proliferation, and
modifying collagen synthesis. Some amino acids are essential for the process, such as
Glutamine and Hydroxymethylbutyrate.
Objective: To evaluate the effect of Glutamine and Hydroxymethylbutyrate supplementation over
the cells involved in wound healing of bloody areas. Hypothesis: Glutamine and
Hydroxymethylbutyrate supplementation promotes a positive effect over the cells involved in
wound healing of bloody areas. Methodology: A randomized controlled clinical trial, in
patients with diagnosis of bloody areas. They will be divided into two groups, the first will
receive an intervention with Glutamine (14g) and Hydroxymethylbutyrate (3g) and a control
group will receive a placebo with calcium caseinate (17g)
A sample of the affected tissue will be taken before and after the supplementation where
histology will be analyzed.
Remains of tissue will be obteined during surgery wash for histology.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05045183 -
A Study to Assess Wound Healing Efficacies of Different Clean, Treat, and Protect Wound Care Regimens Compared to Standard of Care and Untreated
|
N/A | |
| Enrolling by invitation |
NCT04613336 -
Efficacy of Topical Heparin Spray on Donor Site Wound Healing Time Compared to Conventional Dressing Among Patients Undergoing Split Thickness Skin Grafting
|
||
| Recruiting |
NCT02241811 -
Wound Treatment With 3% Sodium Pentaborate Pentahydrate
|
Phase 1 | |
| Completed |
NCT02797899 -
Effect of PRF Palatal Bandage on Pain Scores and Wound Healing After Free Gingival Graft
|
N/A | |
| Completed |
NCT01227759 -
Tyrosur® Gel-Investigation on Wound Healing Efficacy
|
Phase 2 | |
| Completed |
NCT01061502 -
Efficacy Study of a Bioelectric Dressing to Treat Skin Graft Donor Site Wounds
|
Phase 1/Phase 2 | |
| Completed |
NCT00736593 -
A Study Evaluating Nexagon™ in the Treatment of Skin Wounds.
|
Phase 1 | |
| Completed |
NCT00977951 -
Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT03872544 -
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
| Enrolling by invitation |
NCT03880188 -
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
|
||
| Recruiting |
NCT05191082 -
Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate
|
N/A | |
| Enrolling by invitation |
NCT05942235 -
The Use of Microlearning in Nursing Education
|
||
| Completed |
NCT03433820 -
Wound Healing in Healthy Volunteers
|
N/A | |
| Withdrawn |
NCT02383992 -
Postoperative Care of Sutured Wounds
|
N/A | |
| Recruiting |
NCT02034539 -
VADOplex Critical Limb Ischemia Study
|
Phase 2/Phase 3 | |
| Recruiting |
NCT01680042 -
Clinical Effect of Phenytoin Mucoadhesive Paste on Wound Healing After Oral Biopsy
|
Phase 1 | |
| Completed |
NCT01734317 -
An Open Single-centre Investigation Evaluating Efficacy in Second Degree Partial Thickness Burns Using a Silicone Contact Layer Containing Silver.
|
N/A | |
| Withdrawn |
NCT01008111 -
Wound Healing of Incisional Wounds for Bilateral Hernia Repair
|
Phase 1 | |
| Completed |
NCT01115218 -
The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy
|
||
| Terminated |
NCT00177060 -
Topical Hydromorphone for Wound Healing
|
Phase 1/Phase 2 |