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Volume Overload clinical trials

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NCT ID: NCT01617798 Withdrawn - Respiratory Failure Clinical Trials

Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis

SHUM
Start date: June 2012
Phase: N/A
Study type: Interventional

Patients who are on mechanical ventilation in an intensive care unit often require diursis as part of their pre-extubation regimen. The drug of choice for diuresis has traditionally been furosemide. However, this drug cause hypernatremia (a rise in serum sodium) in a significant proportion of patients. Hypernatremia is traditionally treated by providing free water supplementation to the patient. This strategy creates a vicious and unproductive cycle of giving free water, and then diuresing it off. We propose a strategy for breaking this cycle by using a second diuretic-- metolazone-- which has a tendency to rid the body of more sodium, thereby minimizing hypernatremia.