Clinical Trials Logo

Clinical Trial Summary

A comparative study for the surgical treatment of vitiligo in which the same patient will receive in acromic and symmetric lesions of vitiligo dermabrasion with micro needling and on the other side dermabrasion with micro needling followed by the application of cell suspension (melanocytes and uncultured keratinocytes). These cells will be removed from the own patient through the skin of the scalp. After the surgical procedure, patients will be submitted to UVB-NB phototherapy sessions (twice a week) and evaluated for repigmentation of vitiligo lesions at 14 and 24 weeks of treatment.

Clinical Trial Description

Background: Vitiligo is characterized by a depigmentation acquired with partial or total loss of melanocytes from the epidermis, causing great psychosocial impact. Several therapeutic modalities have been proposed for its treatment and surgical treatments have been shown to be promising, especially in recalcitrant cases. The technique of epidermal rasping grafting, a variant of the punch micrografts technique, shows high repigmentation rates and does not require high cost technology. Objective: The objective of this project is to perform a comparative study for the surgical treatment of vitiligo, in which the same patient (N = 10) will receive, in symmetrical acrylic areas, only dermabrasion with a micro needling of 0.25 mm or dermabrasion using micro needling followed of the cell suspension application (melanocytes and uncultured keratinocytes). Methodology: In the donor area (scalp) the healthy tissue will be removed. This tissue will be placed in a sterile container with physiological saline and fragmented with delicate scissors for about 20 minutes until homogeneous consistency of the material is obtained. After the enzymatic digestion of epidermal cells of the dermis, it will isolate melanocytes and keratinocytes that will be placed in the recipient area. After 15 days of the surgical procedure, patients will start the phototherapy UVB-NB sessions (twice a week). The patients will be evaluated about the pain during the procedure, the improvement of injuries of vitiligo and the vitiligo-specific quality-of-life instrument (VitiQoL Vitqol Index) will be applied after and before the treatment. Conclusion: The technique of grafting by epidermal scrap shows high rates of repigmentation and does not require high cost technology, which motivated us, in this study, corroborating the literature and helping to disseminate this technique. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT03497208
Study type Interventional
Source Hospital de Clinicas de Porto Alegre
Contact Roberta Townsend, MD
Phone +5551998280048
Status Recruiting
Phase N/A
Start date March 13, 2018
Completion date December 13, 2019

See also
  Status Clinical Trial Phase
Terminated NCT02191748 - Assessing the Efficacy of Needling With or Without Corticosteroids in the Repigmentation of Vitiligo Phase 2/Phase 3
Completed NCT01382589 - Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo Phase 2
Terminated NCT01262547 - A New Micrografting Technique for Vitiligo Phase 2
Not yet recruiting NCT03611348 - Microneedling and Latanoprost in Acrofacial Vitiligo Phase 2/Phase 3
Recruiting NCT03199664 - Effectiveness of Narrow-band Ultraviolet B Combined With Topical Tacrolimus 0.03% in Treatment of Patients With Vitiligo Phase 4
Recruiting NCT03340155 - Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases N/A
Completed NCT03249064 - Response to Tregs in Innate Immunity Receptor LRP1 (CD91) and Tregs in Periferic Blood Mononuclear Cells in Patients With Non-segmentary Vitiligo N/A
Recruiting NCT02797574 - Stress Response Pathways in Vitiligo N/A
Terminated NCT01259986 - Treatment of Vitiligo With Low-energy Visible Light Laser N/A
Completed NCT03323125 - Photoprotection Habits in Patients With Vitiligo
Recruiting NCT03358082 - Effectivness of Topical Tacrolimus Monotherapy in Patients With Vitiligo Phase 1/Phase 2
Recruiting NCT03270241 - Early Molecular Changes in Vitiligo After Narrowband Ultraviolet Therapy N/A
Completed NCT00398723 - Narrowband UVB Treatment in Patients With Vitiligo N/A
Completed NCT00807690 - Vitiligo Treated With TL01 Combined With Tacrolimus Ointment Versus Placebo Phase 3
Terminated NCT00177034 - Examination Of Vitiligo Skin Samples Before and After UVB Treatment N/A
Completed NCT00134368 - Study of the Efficacy and Safety of Etanercept in Adults With Vitiligo Phase 2
Recruiting NCT03384342 - Maintenance Therapy of Narrow-band UV-B Therapy in Patients With Vitiligo N/A
Recruiting NCT03384459 - Maintenance Therapy of 308-nm Excimer Laser Therapy in Patients With Vitiligo N/A
Recruiting NCT03365141 - Efficacy of Intralesional Triamcinolone Injection in the Treatment of Vitiligo N/A
Not yet recruiting NCT01459055 - Long-term Follow-up in Patients Affected With Acrofacial Vitiligo N/A