Vitiligo Clinical Trial
Official title:
Atorvastatin in Active Vitiligo: a Bicentric Prospective Randomized Trial
Condition:
Non segmental and active vitiligo of adulthood.
Main objective:
To evaluate the efficacy of a daily treatment with atorvastatin 80mg/d combined to UVB
compared to UVB alone in active vitiligo after 6 months of treatment.
Methods:
Prospective interventional bicentric study with evaluation blinded to the treatment received.
Inclusion criteria:
Patients from 18 to 75 year-old with active non segmental vitiligo. Active is defined by the
apparition or the modification of vitiligo lesions with the past 3 months and under Wood's
lamp examination hypochromic borders and/or spotty depigmentation.
Interventions:
After central randomization
- Arm A : atorvastatin 40mg/d for 1 months then 80mg/d for 5 months combined with twice
weekly narrowband UVB treatment for 6 months.
- Arm B: with twice weekly narrowband UVB treatment for 6 months.
Evaluation:
Main criteria: Decrease of VASI score expressed in percentage Secondary criteria: Decrease of
VETF score expressed in percentage. Variation of PGA and DLQI scores. Clinical and biological
tolerance. Variation of CXCL10 levels in the serum.
Length of the study:
Inclusion period: 12 months. Length of treatment: 6 months. Statistical analyses and drafting
the article: 6 months. Total length: 24 months.
n/a
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