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Vertebrobasilar Insufficiency clinical trials

View clinical trials related to Vertebrobasilar Insufficiency.

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NCT ID: NCT06301776 Recruiting - Brain Disease Clinical Trials

A Prospective, Experimental, Multicenter, Open-label, Randomized, Controlled Trial of 3-month Dual Antiplatelet Therapy Followed by Ticagrelor Versus 6-month Dual Antiplatelet Therapy Followed by Ticagrelor After Implanting Bridge

Start date: December 5, 2023
Phase: N/A
Study type: Interventional

To compare the incidence of the composite endpoints of non-fatal ischaemic stroke, transient ischaemia (TIA) and all-cause mortality at 12-month follow-up after implantation of Bridge for the treatment of symptomatic vertebral artery stenosis in subjects who had been taking different durations of dual-antiplatelet therapy (3 vs 6 months) and ticagrelor monotherapy.

NCT ID: NCT06186024 Recruiting - Brain Diseases Clinical Trials

A PROSPECTIVE, MULTICENTER, SINGLE-ARM TRIAL FOR THE NEW SIZES OF BRIDGE STENTS FOR VERTEBRAL ARTERY STENOSIS: Bridge-MAX

Start date: September 27, 2023
Phase: N/A
Study type: Interventional

Aprospective, multicentre, single-arm clinical trial in which approximately 36 subjects would be enrolled using the Bridge 4.5 mm and 5.0 mm stent in accordance with the inclusion and exclusion criteria in this protocol. The success rate of immediate post-procedure stent target lesion treatment was recorded for all subjects, and the incidence of in-stent restenosis (≥50% stenosis) was assessed by DSA imaging follow-up at 6 months (±30 days) post-procedure. The subjects were also followed up at 30 days (±7 days), 6 months (±30 days), and 12 months (±60 days) after stent implantation to assess safety events during the follow-up period. .

NCT ID: NCT06129721 Completed - Acute Stroke Clinical Trials

Emergent Stenting In Acute Vertebrobasilar Occlusions

ESVO
Start date: December 1, 2020
Phase: N/A
Study type: Interventional

In the acute posterior circulation strokes, the vertebrobasilar occlusions frequently related to worse outcomes than the anterior ones. However, few studies mentioned the benefit and safety of the emergent stenting in the successful recanalization at these complex occlusions. The investigators investigated whether the improvement of clinical outcome was achieved in postprocedural 3-month.

NCT ID: NCT05885932 Recruiting - Ischemic Stroke Clinical Trials

Drug-eluting Stenting Versus Medical Treatment for Extracranial Vertebral Artery Stenosis

VISTA
Start date: August 25, 2023
Phase: N/A
Study type: Interventional

Posterior circulation stroke accounts for 20% of all ischemic stroke. Approximately one quarter of posterior circulation strokes are due to stenosis in the vertebral artery and basilar artery. Two previous randomized controlled trials focusing on vertebral artery stenting, the Vertebral Artery Stenting Trial (VAST) and the Vertebral Artery Ischaemia Stenting Trial (VIST) were underpowered because they failed to reach target recruitment, and both the trials found no difference in risk of the primary outcome between the stenting group and medical group. The drug-eluting stenting versus medical therapy alone for patients with extracranial vertebral artery stenosis (VISTA) trial, is a government-funded, prospective, multicenter, randomized controlled trial. It will recruit patients with 3 months stroke or TIA caused by 70-99% stenosis of extracranial vertebral artery (V1-2 segments). Only high-volume center with a proven track record will enroll patients. Patients will be randomized (1:1) to best medical treatment alone or medical treatment plus stenting. Primary outcome is a composite of any fatal or non-fatal stroke within 30 days after randomization, or ischemic stroke in the territory of the target artery beyond 30 days to 1 year. The VISTA trial will be conducted in 30 sites in China and aims to have a sample size of 472 subjects (stenting, 236; medical treatment, 236). Recruitment is expected to be finished by Sep, 2025. Patients will be followed for 1 year at first stage. Long-term follow-ups till 3 years or longer is also preplanned. The first stage of the trial is scheduled to complete in 2027.

NCT ID: NCT05644314 Recruiting - Ischemic Stroke Clinical Trials

Efficacy of Drug-Eluting Vertebral Artery Stenting Treatment for Atherosclerotic Vertebral Arteries Stenosis

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

This is a prospective, multi-center, open-access, single-arm trial to observe the real-world clinical efficacy of drug-eluting vertebral artery stenting system treatment for Atherosclerotic Vertebral Arteries Stenosis. Patients will be followed at 30 days, 6, and 12 months post-procedure and annually for 1 year within 3 years.

NCT ID: NCT05503212 Completed - Ischemic Stroke Clinical Trials

Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions

BRAVO
Start date: January 1, 2003
Phase:
Study type: Observational

Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes. If the two recent ATTENTION and BAOCHE randomized clinical trials have proven the superiority of endovascular thrombectomy (EVT) in basilar artery occlusions, data on the effectiveness and harm of acute revascularization treatment on isolated VAO is scarce. We aim to investigate the impact of acute recanalisation treatments in acute ischemic stroke patients with isolated VAO. In the absence of RCT, observational data with appropriate statistical methods may give indications on benefits and harms of treating neglected stroke situations like acute vertebral occlusion. Results may also lay the basis for prospective studies, such as randomized clinical trials.

NCT ID: NCT05019391 Not yet recruiting - Clinical trials for Vertebrobasilar Insufficiency

Clinical and Radiological Evaluation of Patients With Vertebrobasilar Insufficiency in Assiut University Hospital

Start date: November 2021
Phase: N/A
Study type: Interventional

Clinical and radiological evaluation including transcranial Doppler of vertebral arteries of patients with vertebrobasilar insufficiency attending assiut university hospital and assessment of possible risk factors that may lead to vertebrobasilar insufficiency.

NCT ID: NCT04054440 Enrolling by invitation - Clinical trials for Peripheral Arterial Disease

Outpatient Office Based Endovascular Procedures

Start date: June 20, 2014
Phase:
Study type: Observational

The results of this study will serve as a starting point for future trials concentrating on the effectiveness and clinical outcomes of the procedures performed in an office based angiosuite. Additionally, other studies could compare clinical outcomes between procedures performed in an office based angiosuite and other settings.

NCT ID: NCT03999983 Active, not recruiting - Clinical trials for Vertebral Artery Stenosis

Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER)

VOTER
Start date: November 19, 2019
Phase:
Study type: Observational [Patient Registry]

A prospective registry of patients admitted for stroke and evidence of Vertebral Artery Origin Stenosis (VAOS).

NCT ID: NCT03859674 Completed - Clinical trials for Vertebral Artery Stenosis

Firehorus Rapamycin Target Eluting Vertebral Artery Stent System in Clinical Application

Start date: July 17, 2014
Phase: N/A
Study type: Interventional

This clinical trial uses a prospective, multicenter, single-arm, objective performance criteria-design, aiming to evaluate the safety and effectiveness of Firehorus Rapamycin Target Eluting Vertebral Artery Stent System .