Understanding Poor Vaccine Responses to Hepatitis B Vaccination

Status Recruiting

Clinical Trial Summary

Vaccines have prevented countless infections but poor vaccine responses remain a major challenge in many scenarios. Hepatitis B vaccine nonresponses are common but immunologically not well-understood. This study aims to study the immunology of hepatitis B vaccine responses by comparing traditional HBV vaccine, which is associated with nonresponses in some patients, to CpG-adjuvanted HBV vaccine, which is associated with far fewer rates of nonresponses. This research will build upon prior studies of the human immune response to infection to gain a deeper understanding of the complexity of these responses. This information will be broadly useful as many vaccine candidates fail due to lack of immunogenicity, potentially enabling improved vaccine design and better protection.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04674462
Study type	Interventional
Source	NYU Langone Health
Contact	Ramin Herati, MD
Phone	646-477-9086
Email	Ramin.Herati@nyulangone.org
Status	Recruiting
Phase	Phase 4
Start date	July 7, 2022
Completion date	July 2026

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