Ulcerative Colitis Clinical Trial
Official title:
Tolerability and Efficacy of Low-Volume Sodium Picosulfate/Magnesium Citrate Versus 2L Polyethylene Glycol/Ascorbic Acid in Patients With Ulcerative Colitis Undergoing Colonoscopy: A Randomized Controlled Trial
Ulcerative colitis is a chronic condition that results in the inflammation of the colon and
rectum. Patients suspected to have ulcerative colitis are diagnosed via colonoscopy.
Moreover, colonoscopy is considered to be the preferred procedure for assessing the activity
and extent of the disease, as well as monitoring treatment response and development of
lesions. Therefore, optimal performance and visualization of mucosal lesions via adequate
bowel preparation is essential in such patients. In addition, the nature of the disease and
the need for multiple colonoscopies throughout a patient's lifetime makes compliance to
repeated procedures difficult.
It is well known that colonoscopy preparations are generally poorly tolerated, disliked and,
consequently serve as an additional burden on patients.Polyethylene glycol (PEG), despite
being the golden standard, is not very well tolerated. Inadequate bowel preparations are
associated with cancelled procedures, prolonged procedure time, incomplete examination,
increased cost and possibly complications, physician frustration and patient anxiety, but
most importantly, with missed pathology. A good bowel preparation would need a solution with
reasonable volume, acceptable taste, minimal diet restrictions, and easy-to-follow
instructions. The strict need for adherence to drinking a relatively large volume of solution
preparation may result in poor compliance.
Despite the emergence of several types of low volume preparations, the evidence on the use of
such solutions remains sparse. This is especially true in terms of patients' tolerability to
the solution, and its relation with adequate bowel preparation during colonoscopy.
The investigator's aim is to assess how small volume preparations such as sodium
picosulfate/magnesium citrate (Citrafleet®) enhance participants tolerability to the
solution, compliance, and adequacy of bowel preparations when compared to 2L polyethylene
glycol + ascorbic acid (MoviPrep®) in patients with Ulcerative Colitis.
n/a
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