Healthy Clinical Trial
Official title:
Threonine Requirement in Healthy Adult Subjects and in Patients With Crohn's Disease and With Ulcerative Colitis Using the Indicator Amino Acid Oxidation (IAAO) Methodology
The daily requirement of threonine, an essential amino acid, will be evaluated in healthy adult males and in adult males with Crohn's Disease or ulcerative colitis using the indicator amino acid oxidation (IAAO) method. Participants will consume specially formulated diets with varying levels of threonine.
Threonine is an essential amino acid which must be obtained from the diet. It is a component
of mucin. Mucin, in turn, is a key protein in the mucous membrane that protects the lining of
the intestine.
Inflammatory bowel disease (IBD) is a group of inflammatory conditions that affect the colon
and small intestine. IBD primarily includes ulcerative colitis (UC) and Crohn's disease (CD).
In UC, the inflammation is usually in the colon whereas in CD inflammation may occur anywhere
along the digestive tract. Studies in animals have shown that more threonine is used when
there is inflammation in the intestine.
The threonine requirement in healthy participants and in IBD patients will be determined
using the indicator amino acid oxidation method. The requirement derived in healthy
participants will be compared to that derived in patients with IBD.
Each participant will take part in two x 3 day study periods. The first two days are called
adaptation days where the subjects will consume a liquid diet specially designed for him. The
diet will be consumed at home. It contains all vitamins, minerals, protein and all other
nutrients required. On the third day, the participant will come to the Hospital for Sick
Children in Toronto. Subjects will consume hourly meals for a total of 8 meals and a stable
isotope 13C-phenylalanine. Breath and urine samples will be collected to measure the
oxidation of phenylalanine from which the threonine requirement will be determined.
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