Exenatide Plus Pioglitazone Versus Insulin in Poorly Controlled T2DM

Status Recruiting

Clinical Trial Summary

To compare efficacy, safety and durability of combination therapy with pioglitazone plus GLP-1 RA versus basal bolus insulin in poorly controlled T2DM patients on metformin plus sulfonylurea

Clinical Trial Description

poorly controlled (HbA1c >7.5%) T2DM patients (18-75 years of age) on maximal/near maximal dose of sulfonylurea plus metformin who otherwise are healthy will be randomized to receive:

1. exenatide weekly injection (2 mg/week)

2. glargine insulin plus insulin aspart which will be titrated to maintain HbA1c <7.0% ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Type 2 Diabetes

Clinical Trial Details

NCT number	NCT02887625
Study type	Interventional
Source	Hamad Medical Corporation
Contact	Muhammad Abdul-Ghani, MD, PhD
Phone	44391208
Email	ABDULGHANI@UTHSCSA.EDU
Status	Recruiting
Phase	N/A
Start date	February 2015
Completion date	May 2017

View Details

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