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Type 2 Diabetes clinical trials

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NCT ID: NCT05762744 Terminated - Type 2 Diabetes Clinical Trials

Pharmacogenomics of GLP1 Receptor Agonists

Start date: June 1, 2016
Phase: Phase 1
Study type: Interventional

Healthy volunteers were recruited from the Old Order Amish population in Lancaster County, Pennsylvania. After providing informed consent, research participants were screened for eligibility. The clinical trial was designed as a randomized crossover study in which participants underwent two frequently sampled intravenous glucose tolerance tests - one after receiving a subcutaneous injection of saline and one after receiving a subcutaneous injection of rapid-acting exenatide (BYETTA). The study sought to determine whether genetic variants are associated with the magnitude of the effect of exenatide. If an association were identified, this would help physicians to predict whether an individual patient is likely to have a large response to the class of diabetes drugs to which exenatide belongs (GLP1 receptor agonists).

NCT ID: NCT05694741 Terminated - Type 2 Diabetes Clinical Trials

A Study to Assess Safety, Tolerability, and Pharmacokinetics of AZD0186

Start date: December 20, 2022
Phase: Phase 1
Study type: Interventional

This study will assess the safety, tolerability, and pharmacokinetics of AZD0186 following single ascending doses (SAD) via oral administration in healthy adult participants.

NCT ID: NCT05510245 Terminated - Type 2 Diabetes Clinical Trials

A Clinical Trial of the Study Medicine (PF-07081532) in People With Diabetes and Kidney Dysfunction

Start date: August 29, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to understand the effects of kidney functional impairment may have on the study medicine (PF-07081532). People with certain level of kidney functional impairment may process PF-07081532 differently from healthy people. PF-07081532 is developed as a potential treatment for type II diabetes. Participants will take the study medicine as a tablet by mouth once at the study clinic and then will stay at the study clinic for about 7 days. During that time, the study team will monitor their treatment experience and take some blood samples to test the level of PF-07081532. This will help us understand if certain degree of kidney functional impairment will have an effect on the study medicine PF-07081532.

NCT ID: NCT05504785 Terminated - Type 2 Diabetes Clinical Trials

DexCom Hospital Study-CGM Directed Insulin Delivery

Start date: August 1, 2020
Phase: N/A
Study type: Interventional

This is a pilot investigator initiated/sponsored clinical trial to evaluate the feasibility of using real-time DexCom G6 continuous glucose monitor (CGM or glucose sensor) trend data and an insulin-dosing algorithm to control the glucose levels of type 2 diabetic patients undergoing hip/knee orthopedic surgery at Thomas Jefferson University Hospital (TJUH). Blinded CGM glucose data will be recorded prior to hospital admission, during hospital admission, and after hospital discharge to evaluate glucose control in this diabetic patient population in relationship to clinical outcomes (20 days of recorded blinded CGM data maximum). Prior studies have associated hyperglycemia, hypoglycemia, and glycemic variability with an increased incidence of nosocomial infection, deep vein thrombosis, pulmonary embolism, cardiac arrhythmias, mental status changes, hospital length of stay, and cost. The 20 type 2 diabetic patients in the Control Group will be managed according to standard-of-care methods at TJUH using finger-stick blood glucose measurements in an attempt to maintain the patient's blood glucose levels in the desired target range (80 to 180 mg/dL). Three blinded CGM will be used to record the patient's glucose trend data for future download to a computer and analysis. The 40 type 2 diabetic patients in the Investigational Group will be managed by the orthopedic floor nurses using the real-time DexCom G6 CGM trend data to determine the appropriate therapy to maintain the patient's glucose levels in the desired target range (80 to 180 mg/dL). In addition, three blinded CGM will be used to record the patient's glucose trend data for future download to a computer and analysis. The primary objective of this pilot study is to observe the blood glucose values and glucose sensor (CGM) values of diabetic patients before, during and after hospitalization for hip and knee arthroplasty surgery to determine whether there is a correlation between glucose control and clinical outcomes. This pilot data will be used to plan a future clinical trial in orthopedic surgery patients using CGM to determine patterns of hyperglycemia, hypoglycemia, and glycemic variability that correlate with clinical complications, hospital length of stay, and cost.

NCT ID: NCT05267925 Terminated - Type 2 Diabetes Clinical Trials

CuraLin Herbal Supplement for Type 2 Diabetes

Start date: January 8, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to provide preliminary data necessary for a larger, controlled trial of CuraLin as a treatment option for T2DM. This study will also fill the gap in literature surrounding herbal medicine in the treatment of T2DM. The use of herbal preparations for diabetes has increased globally, and given the costs, adverse effects, lack of clinical outcome improvement, and minimal A1c reductions associated with medications, safer, more affordable alternatives need to be explored. CuraLin™ is a dietary supplement manufactured by NutraStar Inc. and sold by CuraLife; it is a blend of nine ayurvedic plants and herbs taken three times daily, after meals for the management of diabetes. It is hypothesized that CuraLin will be safely tolerated among adults with Type 2 Diabetes Mellitus, and will improve glucose control and cardiometabolic risk factors over this 12 week study.

NCT ID: NCT04892680 Terminated - Type 2 Diabetes Clinical Trials

Impact of a Digital Self-Management Program on A1C for Individuals With Type 2 Diabetes

Start date: March 4, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to evaluate a digital chronic disease self-management program designed to provide virtual support and guidance for patients with type 2 diabetes.

NCT ID: NCT04822740 Terminated - Type 2 Diabetes Clinical Trials

Evaluation of Continuous Glucose Monitoring in Patients With ACS and Type 2 Diabetes in ICU

EVASION
Start date: December 7, 2022
Phase: N/A
Study type: Interventional

The investigators hypothesize that the use of a continuous glucose monitoring system (CGMS) can reduce glycemic variability assessed by coefficient of variation (CV) during the acute phase of acute coronary syndrome (ACS) in patients with diabetes treated by insulin infusion. The purpose of this project is to assess the impact of the use of CGMS on glycemic variability in diabetic patients with ACS . This is a randomized, multicenter (2 centers), open study. The patients included, as soon as possible, after admission will be randomized before the beginning of insulin therapy with intravenous insulin .

NCT ID: NCT04567225 Terminated - Type 2 Diabetes Clinical Trials

Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management

Start date: October 1, 2020
Phase: Phase 4
Study type: Interventional

Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management

NCT ID: NCT04365400 Terminated - Type 2 Diabetes Clinical Trials

Assess Efficacy and Safety of Epeleuton in Patients With Hypertriglyceridemia and Type 2 Diabetes

TRIAGE
Start date: October 13, 2020
Phase: Phase 2
Study type: Interventional

To assess the efficacy and safety of orally administered Epeleuton capsules versus placebo, in the treatment of adult patients with hypertriglyceridemia and type 2 diabetes

NCT ID: NCT04234581 Terminated - Type 2 Diabetes Clinical Trials

The Effect of Lysulin on Glycemic Control and Advanced Glycation

Start date: August 13, 2019
Phase: N/A
Study type: Interventional

The primary objective is to determine whether 12 weeks of treatment with Lysulin, compared to placebo, causes a reduction from baseline in the plasma levels of glucose, hemoglobin A1c (HbA1c) and Advanced Glycation Endproducts (AGEs) in patients with inadequately controlled type 2 diabetes mellitus. Secondary objectives include determining whether 12 weeks of treatment with Lysulin increases beta-cell function as measured by plasma C-peptide levels.