Type 2 Diabetes Mellitus Clinical Trial
Official title:
Acute Effects of a Low-AGE vs. High-AGE Meal on Postprandial Endothelial Function in People With Type 2 Diabetes Mellitus. Protective Effects of Benfotiamine
The purpose of the study is to determine whether there are differences in postprandial endothelial function following a high-AGE(Advanced Glycation End-products) meal vs. a low-AGE meal. We also intend to investigate if the therapy with 1050mg Benfotiamine for 3 days protects against the postulated deterioration of endothelial function after a high-AGE meal in people with type 2 diabetes mellitus.
AGEs are a heterogeneous group of compounds formed by the nonenzymatic reaction of reducing
sugars with proteins, lipids and nucleic acids. Diet has been recognized as an important
exogenous source of AGEs. There is evidence for the implication of AGEs in the pathogenesis
of diabetes-related complications, atherosclerosis, ageing processes or Alzheimer´s disease.
Although, only little information exists about their effects in humans. The hypotheses of
this study are that a high-AGE meal leads to a more important acute vascular dysfunction
comparing to a low-AGE meal, and that a 1050mg/day Benfotiamine therapy for 3 days has a
protective effect on the endothelial function.
Twenty-one people with type 2 diabetes shall be investigated in a randomized, single-blinded
(investigator), cross-over design (please compare design description).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind, Primary Purpose: Prevention
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