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Trypanosomiasis, African clinical trials

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NCT ID: NCT05466630 Recruiting - Sleeping Sickness Clinical Trials

Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis

SpeSerTryp
Start date: June 20, 2022
Phase: N/A
Study type: Interventional

This study evaluates and compares the diagnostic specificity of 5 serological field tests for screening of the population at risk for human African trypanosomiasis due to Trypanosoma brucei gambiense.

NCT ID: NCT05433350 Recruiting - Clinical trials for Trypanosomiasis, African

Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients

OXA005
Start date: July 15, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

Acoziborole has been studied in an open-label pivotal Phase II/III trial (DNDi-OXA-02-HAT) in the DRC and Guinea. As the numbers of reported cases diminish, resources for surveillance and specialised screening will also taper. This decrease, coupled with the loss of diagnostic skills and disease management expertise, will lead to a weak and less specialised HAT technical environment. The history of g-HAT has shown that outbreaks or re-emergence of the disease have already happened under different circumstances when surveillance was relaxed or simply because the populations at risk live in areas of political instability, limiting access to specialised care. Even with a steady decrease of reported incidence, no model can currently predict that HAT could not re-emerge. Although g-HAT is predominantly a disease of adults, children are also affected at diverse rates depending on the geographical and behavioural characteristics in the different areas of disease transmission. Hence efforts are needed to develop a paediatric formulation from a new generation of oral HAT treatments.