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PF-04995274 and Emotional Processing in Treatment Resistant Depression — RESTART  

Treatment Resistant Depression Clinical Trial

Official title:
The Effects of PF-04995274 on Emotional Processing in Treatment-resistant, Medicated, Depressed Patients

Clinical Trial Summary

This study will test whether seven days adjunctive administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on emotional processing and non-emotional cognition in medicated, treatment-resistant depressed patients compared to placebo.

Clinical Trial Description

This study uses a double-blind, placebo-controlled, randomised between-groups design to test if adjunctive administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on emotional processing and neural activity in medicated treatment-resistant depressed patients. Participants are patients who fulfill criteria for current episode of Major Depressive Disorder (MDD) and have shown lack of response to antidepressant treatment, and they will be randomised to receive 7 days treatment with either PF-04995274 (15 mg daily) or a matched placebo. Participants will come for a Screening Visit, a First Dose Visit, and a Research Visit (including measures of emotional processing and non-emotion cognition). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03515733
Study type Interventional
Source University of Oxford
Contact
Status Completed
Phase Phase 1
Start date May 31, 2018
Completion date July 26, 2022
View Details
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