Transient Ischemic Attack Clinical Trial
Official title:
Cognitive Changes and Rehabilitation in People With Transient Ischemic Attack, Stroke, or Stroke Risk Factors
Stroke is a leading cause of disability; most strokes (80%) are subcortical, with ischemic
damage due to occlusion in penetrating arteries. Although ischemic white matter disease
(iWMD) may lack gross clinical manifestation, it causes significant cognitive impairment,
particularly on measures of executive function, attention, and memory. This impairment is
attributable to diffuse damage affecting network connections.
While there are many studies concerning rehabilitation of motor function and language in
patients with large focal strokes, few studies have addressed attentional and executive
functions. To our knowledge, there are no such studies on iWMD. In this study, patients will
be randomized to a novel intervention for improving executive function and a control
condition matched for therapist exposure. Patients will be assessed pre-intervention,
post-intervention, and at long-term follow-up using a battery of behavioural and
neuroimaging tasks. We predict that the novel intervention will be associated with improved
executive function, as assessed behaviourally, and improved frontal network function, as
assessed through neuroimaging markers.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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