Total Joint Arthroplasty Clinical Trial
It is widely reported that a large percentage of total joint replacement patients receive
allogeneic (human donor blood) blood transfusions due to perioperative blood loss with
numbers ranging from 30% to 80%.
The risks of allogenic blood transfusion are well documented in the literature. In addition,
they are time-consuming: often lengthening hospital stay and decreasing the availability for
postoperative physical therapy. Moreover, they are costly at several hundred dollars per
unit, and allogeneic transfusions are linked with immunosuppression and increased
postoperative infection rates and wound healing problems, which are devastating
complications in this elective, joint replacement population. Several options are available
for diminishing the need for allogenic blood transfusion following elective total joint
replacement. These include the use of perioperative blood salvage devices (OrthoPAT) and
tranexamic acid. While there is data to support the use of both OrthoPat and Tranexamic acid
in primary total joint arthroplasty, there is little information comparing one versus the
other in terms of efficacy and economics.
The purpose of this study is to compare the safety, effectiveness and cost benefit of
Hemovac drain, OrthoPAT and Tranexamic Acid to manage blood loss during total hip and total
knee replacement surgery.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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