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Tobacco Use clinical trials

View clinical trials related to Tobacco Use.

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NCT ID: NCT06105424 Completed - Smoking Clinical Trials

BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability

Start date: September 24, 2016
Phase: N/A
Study type: Interventional

This will be a single-center, single-blind, four-cohort, 22-day ambulatory study during which up to 24 healthy adult subjects [6 smokers (SMK), 6 moist snuff consumers (MSC), 6 vapers (VAP), and 6 non-tobacco consumers (NTC)] will complete 3 measurements of lung permeability. Nasal epithelial cells, sputum, and blood samples will also be collected for current and future biomarker research.

NCT ID: NCT05849051 Completed - Tobacco Use Clinical Trials

Little Cigar and Cigarillo Warnings Among US Adults Who Use LCCs

Start date: May 22, 2023
Phase: N/A
Study type: Interventional

The goal of this research is to assess whether little Cigars and cigarillos (LCC) warnings developed by the study team are more effective than the current warnings proposed by FDA for LCC products. A 3-week web-based randomized controlled trial will be conducted in the United States. Participants are adult persons who currently use LCCs.

NCT ID: NCT05730322 Completed - Tobacco Use Clinical Trials

Expanding the Click City Tobacco Prevention Program

Start date: January 6, 2020
Phase: N/A
Study type: Interventional

The goal of this study is to modify a smoking prevention program for 5th and 6th grade students to also target vaping e-cigarettes. Aims were to modify the program along with associated materials and to conduct a trial with 5th grade students in the school setting to see how well the updated program worked. Students either participated in the four-week computer based program or continued with their usual tobacco prevention curriculum. This study showed that students who received the computer program reduced their intentions and willingness to use e-cigarettes or smoke in the future more than did students who used their usual tobacco curriculum.

NCT ID: NCT05664672 Completed - Tobacco Use Clinical Trials

Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches

Start date: May 11, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to generate evidence regarding the extent of reduction in exposure to selected HPHCs in adult smokers switching to on!® NPs. The study intends to determine changes in exposure to selected HPHCs by measuring biomarkers in adult smokers who completely switch from smoking to use of on!® NP compared to those who continue smoking cigarettes or stop using all tobacco products.

NCT ID: NCT05599451 Completed - Smoking Clinical Trials

Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS

Start date: November 16, 2022
Phase: N/A
Study type: Interventional

This is a randomized, controlled, open-label, 4 parallel arm study with a stratified randomization by sex (a quota for each sex [females and males] of at least 40% overall). This study aims to demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected Harmful and Potentially Harmful Constituents (HPHC) in smokers switching from cigarettes (CIG) to each of the Tobacco Heating System (THS) variants with different heating technology (Blade device, Induction Mono device, or Induction Mid device, respectively), compared with smokers who continue to smoke CIG. A reduction of exposure to HPHC is expected in CIG smokers when switching completely to THS.

NCT ID: NCT05525078 Completed - Tobacco Use Clinical Trials

Quit or Switch: E-cigarette Study

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

The majority of smokers try to quit each year, and the majority of quit attempts fail, even when the most effective FDA-approved pharmacotherapies are used. Non-combustible tobacco products emit fewer harmful chemicals than cigarettes, and thus for smokers who cannot quit smoking, switching completely to a less harmful product is likely to improve their risk of cancer and other deleterious health outcomes. E-cigarettes, the most commonly used non-cigarette tobacco product, have been shown to deliver sufficient nicotine, be appealing to smokers, and reduce cigarette smoking when provided to smokers to use ad libitum. For smokers who have failed to quit with traditional methods, trying to switch to a less harmful product may be more likely to help them stop smoking than trying to quit using tobacco altogether repeatedly with pharmacotherapy. The proposed trial evaluates the potential of e-cigarettes to serve as harm reduction tools for current smokers who have already tried, and failed, to quit with traditional methods. Current smokers who failed to quit with FDA-approved pharmacotherapy within the past year (N=30) will be randomly assigned to either 1) switch completely to e-cigarettes (Switch Group, n=20), or 2) try to quit again using pharmacotherapy (Meds Group, n=10). Thus, our design is strengthened by a strong active control group. Participants will select a Target Switch / Quit Date on which they will stop smoking. Participants in the Switch group will receive a 5-week supply of JUUL e-cigarettes, the most popular e-cigarette currently available. Participants in the Meds Group will receive a 5-week supply of combination nicotine replacement therapy (transdermal nicotine patch and short-acting nicotine lozenge). Participants will use 1-week of their tobacco product or medication ad libitum while continuing to smoke in advance of their Target Switch / Quit Date, and 4-weeks as instructed following a Target Switch or Quit Date. Behavioral outcomes of interest include smoking reduction > 50% and biochemically-confirmed abstinence from cigarette smoking at 4-weeks. The proposed trial addresses a highly significant research question using a rigorous design and is supported by a strong investigative team.

NCT ID: NCT05447156 Completed - Clinical trials for Tobacco Use Disorder

QuitGuide for American Indians: Aims 2 & 3

Start date: December 14, 2022
Phase: N/A
Study type: Interventional

Aim 2: To assess the preliminary feasibility and acceptability of a tailored smoking cessation app prototype (here forward called tailored QuitGuide) among American Indian (AI) smokers. Aim 3: To test feasibility, acceptability, and preliminary efficacy of the tailored QuitGuide for smoking cessation among AIs.

NCT ID: NCT05409963 Completed - Tobacco Use Clinical Trials

Tobacco Impact on Quality of Life on Snus-use, Dual Use, Smoke Use and Non-using.

Start date: November 18, 2010
Phase:
Study type: Observational

The primary aim of this study was to compare HRQOL in snus-users and dual users (snus and smoking) with never tobacco users. Secondary aim included comparing HRQOL in smokers with non-smokers.

NCT ID: NCT05362318 Completed - Lung Cancer Clinical Trials

Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free

Start date: June 7, 2021
Phase: N/A
Study type: Interventional

The purpose of the study is to pilot test a multi-modal smoking cessation and relapse prevention intervention with the lung cancer patient population and to obtain preliminary data on its feasibility.

NCT ID: NCT05320887 Completed - Tobacco Use Clinical Trials

Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)

Start date: July 27, 2022
Phase: N/A
Study type: Interventional

This study is proposing a four condition Electronic Tobacco Marketplace (ETM) study to determine if banning normal nicotine content (NNC) is sufficient for encouraging smokers to switch to potentially less harmful products or if the availability of higher nicotine and/or flavored alternative products (specifically e-cigarettes) are needed to achieve maximal reductions in smoking.