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Tinea Cruris clinical trials

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NCT ID: NCT05881980 Not yet recruiting - Tinea Cruris Clinical Trials

Efficacy and Safety of Terbinafine and Itraconazole

Start date: May 2023
Phase: Phase 2/Phase 3
Study type: Interventional

There is a rise in the prevalence in recent years especially in tropical countries along with an increase in the number of treatment failures with chronic and recurrent dermatophytosis. There is a huge gap between the treatment required in the present scenario and the treatment guidelines given in the standard books. The aim of the study is to determine the effectiveness of terbinafine and itraconazole in different doses and in combination in the treatment of dermatophytosis. The study design will be a randomized parallel-group trial. Patients will be randomly divided into five parallel arms in which two of the standard drugs in recommended doses will be compared with their double doses and with a combination of both drugs. The patients will be reevaluated at 2, 4, 6, and 8 weeks of treatment (the end of therapy), using the physician Global Assessment (PGA) Scale. The cure will be considered a complete clinical resolution of the lesions. The patient's response to the treatment will be recorded. Safety and patient compliance will be recorded at each follow-up visit. Findings of observation will be recorded on a pre-prescribed and pre-tested data collection form. After collection, all data will be checked and compiled. Data will be processed and analyzed using computer software with statistical packages for social science SPSS-26. An analysis plan will be developed keeping in view the objectives of the study. The results of the continuous measurement will be presented on mean ± SD (mean-max) and results on categorical measurements will be presented in numbers (%). A p<0.05 will be considered statistically significant. Results will be disseminated to all Dermatology departments in Bangladesh.

NCT ID: NCT05363449 Recruiting - Tinea Pedis Clinical Trials

Safety, Tolerability, and Pharmacokinetics of UHE-103 Cream in Subjects With Tinea Cruris and/or Tinea Pedis

Start date: February 17, 2022
Phase: Phase 1
Study type: Interventional

This Phase 1 study has been designed to determine the safety, tolerability and pharmacokinetics (PK) of UHE 103 Cream compared to Naftin Cream, 2% under maximal use conditions for 2 weeks treatment in subjects with tinea cruris and/or tinea pedis

NCT ID: NCT03359070 Completed - Tinea Cruris Clinical Trials

Clinical Trial Comparing Dapaconazole Versus Miconazole in Patients With Tinea Cruris

Start date: January 29, 2014
Phase: Phase 2
Study type: Interventional

This trial aims to evaluate the efficacy of dapaconazole tosylate 2% cream in the treatment of Tinea cruris compared to the active control miconazole nitrate 2% cream in patients with a single lesion.

NCT ID: NCT02767271 Completed - Tinea Pedis Clinical Trials

Maximal Use of Luliconazole Cream 1% in Pediatric Participants With Moderate to Severe Tinea Pedis or Tinea Cruris

Start date: December 2, 2015
Phase: Phase 4
Study type: Interventional

The objective of this study is to evaluate the pharmacokinetics of luliconazole cream 1%, as measured by circulating plasma levels of luliconazole, when maximal quantity of luliconazole cream 1% is applied to participants of 12 years to less than (<) 18 years of age with moderate to severe inter-digital tinea pedis or tinea cruris.

NCT ID: NCT02394340 Completed - Tinea Pedis Clinical Trials

Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Participants With Tinea Pedis and Tinea Cruris

Start date: February 3, 2015
Phase: Phase 4
Study type: Interventional

This is an open-label, maximal use study to evaluate whether luliconazole in plasma acts as an inhibitor of cytochrome P2C19 (CYP2C19) as measured by circulating levels of omeprazole before and after treatment with a maximum dose of luliconazole cream 1% in participants with moderate to severe tinea pedis and tinea cruris.

NCT ID: NCT01885156 Completed - Tinea Cruris Clinical Trials

Evaluation of Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris

Start date: August 2013
Phase: Phase 3
Study type: Interventional

To see how well Naftin 1% cream works when applied once daily to the affected area. The results will be compared to those using a placebo cream, which is a cream with no active ingredient. Safety will also be measured.

NCT ID: NCT01712360 Completed - Tinea Pedis Clinical Trials

Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis

Start date: October 2012
Phase: Phase 4
Study type: Interventional

This study is being done to see how the body is affected when a study drug is applied to both feet if the subject has athlete's foot or to both feet and the groin area if the subject have both athlete's foot and jock itch. Safety of the drug and how well the drug works will also be measured.

NCT ID: NCT01349998 Completed - Tinea Pedis Clinical Trials

Safety of a Topical Antifungal Treatment for Tinea Cruris, Tinea Pedis and Tinea Corporis

Start date: May 2011
Phase: Phase 3
Study type: Interventional

The purpose of this study is to examine the long-term safety of treating recurrent episodes of tinea pedis for 14 days for each recurrence and recurrent episodes of tinea corporis or tinea cruris for 7 days for each recurrence with Product 33525.

NCT ID: NCT01342315 Completed - Tinea Cruris Clinical Trials

Topical Antifungal Treatment for Tinea Cruris

Start date: May 2011
Phase: Phase 3
Study type: Interventional

To determine if a topical antifungal cream is safe and effective for the treatment of tinea cruris

NCT ID: NCT01105013 Not yet recruiting - Tinea Pedis Clinical Trials

Evaluate the Efficacy and Safety of Tolnaftate Cream in the Treatment of Patients With Fungal Infections

Tonaftato
Start date: April 2012
Phase: Phase 3
Study type: Interventional

This is a study clinical, multicenter, Phase III trial, to evaluate the efficacy and safety of tolnaftate cream in the treatment of patients with fungal infections such as Tinea foot, Tinea and Tinea crural body.