Systemic Lupus Erythematosus Clinical Trial
Official title:
Does DHEA Improve Endothelial Dysfunction and Other Cardiovascular Risk Factors in Premenopausal Women With Systemic Lupus?
The purpose of this study is to evaluate the effect of DHEA on endothelial dysfunction in
patients with systemic lupus by measuring:
1. changes in brachial artery flow-mediated dilatation (FMD) and
2. changes in biomarkers of cardiovascular risk. Patients will be enrolled in a
randomized, double-blinded crossover trial of DHEA or placebo for ten weeks, then
crossed over to the alternate treatment arm after a six-week washout period.
HYPOTHESIS: Dehydroepiandrosterone (DHEA) administration in premenopausal women with SLE
modifies cardiovascular risk by improving vascular endothelial function and other biomarkers
associated with cardiovascular heart disease.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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