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Association Between Clinical Effect of Continuous Morphine Administration After Surgery and Pharmacogenetics

Surgery Clinical Trial

Official title:
Association Between Clinical Effect of Continuous Morphine Administration in Patients After Major Surgery and Pharmacogenetics: Perspective Observational Clinical Study

Clinical Trial Summary

Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.

Clinical Trial Description

Valuation of the rescue doses necessary to maintain NRS<4 in the first 24 hours post-surgery in the two groups of patients, A e B. Group A: homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene (about 80%); group B: both homozygous and heterozygous patients for the less frequent allele (about 20%). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01233219
Study type Observational
Source IRCCS Policlinico S. Matteo
Contact
Status Withdrawn
Phase N/A
Start date November 2010
Completion date November 2013
View Details
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