Clinical Trials Logo
NCT number NCT03345394
Study type Interventional
Source Federal University of São Paulo
Contact André M de Queiroz Constantino Miguel, PhD
Phone 11965884111
Status Recruiting
Phase N/A
Start date December 1, 2017
Completion date September 1, 2020

Clinical Trial Summary

Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or have lived in the streets, history of incarceration and engagement in illegal activities. For the last 20 years a treatment called Contingency Management (CM) have achieved the best results regarding reduction of substance use, promotion of abstinence, treatment attendance and retention in treatment. The first CM study conducted in Brazil advocates for the efficacy of CM on all of these outcomes, suggesting that CM can be effective in a Brazilian population of crack users.

Clinical Trial Description

The objective of this study is to evaluate the effectiveness of Contingency Management (CM) for crack users living in the "Crackland" region. To achieve this goal, regular treatment staff from Unidade Helvétia and CRATOD treatment services will be capacitated in CM to latter-on apply the CM intervention in their respective services. The design will be a crossover randomized clinical trial composed of a sample of 200 subjects with current diagnose for crack/cocaine dependence. Participants allocated to the control condition will receive 12 weeks of the usual care treatment provided by these two treatment facilities. Participants allocated to the experimental condition will receive the exact same treatment as control participants associated with CM. CM procedure will occur 2 timer per week (every Monday and Thursday or Tuesday and Friday). After 12 weeks of intervention, participants in the control condition (standard treatment alone) will receive 12 weeks of the experimental treatment (standard treatment plus CM) and participants in the experimental condition will receive 12 weeks of the control procedure. Primary outcomes are: (1)retention in treatment; (2) reduction of crack use; (3) promotion of continuous crack cocaine abstinence. Secondary findings are reduction on psychiatric symptomatology. The investigator hypothesis is that participants will have a better response in all studied outcomes when receiving treatment in the CM condition.

Study Design

Related Conditions & MeSH terms

See also
  Status Clinical Trial Phase
Recruiting NCT02845453 - Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation Phase 4
Recruiting NCT02244138 - Improving Adolescent Health Outcomes Through Preventive Care Transformation N/A
Active, not recruiting NCT02382042 - Intensive Referral Intervention to Improve Substance Use Disorder Treatment Outcomes Among Rural and Highly Rural Veterans N/A
Completed NCT01237366 - Study Targeting Affect Regulation Phase 1/Phase 2
Terminated NCT01356667 - Drum-Assisted Therapy for Native Americans Phase 1
Completed NCT00708890 - Twelve Step Based Self-help Groups for Substance Related Disorders N/A
Recruiting NCT03368794 - Naloxone to TReatment Entry in the Emergency Setting N/A
Recruiting NCT03226223 - Pharmacogenetics of Naltrexone for Stimulant Abuse Phase 2
Recruiting NCT03356210 - Neurofeedback Training for the Treatment of Substance Use Disorders N/A
Recruiting NCT02553616 - An Intervention to Promote Healthy Behaviors in Homeless Youth N/A
Recruiting NCT02629068 - PURPOSE: A Social Media Intervention for Parent Support N/A
Active, not recruiting NCT02081417 - Patient-Centered Trauma Treatment N/A
Completed NCT01948674 - Cognitive Stimulation in Adolescents Phase 2
Recruiting NCT01706380 - 3M Study - Maria Malmö Mobile Telephone Study N/A
Completed NCT01457872 - Malmö Treatment Referral and Intervention Study N/A
Active, not recruiting NCT00734903 - A Randomized Controlled Trial on Women's Substance Abuse Treatment Phase 2
Active, not recruiting NCT01159535 - Mindfulness Based Relapse Prevention: Efficacy and Mechanisms Phase 1/Phase 2
Completed NCT01849029 - Cognitive Processing Intervention for Trauma, HIV/STI Risks, and Substance Use Among Native Women N/A
Recruiting NCT03334721 - Gabapentin for Bipolar & Cannabis Use Disorders Phase 2
Recruiting NCT03333460 - Transcranial Magnetic Stimulation for Cocaine Addiction N/A