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Clinical Trial Summary

Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or have lived in the streets, history of incarceration and engagement in illegal activities. For the last 20 years a treatment called Contingency Management (CM) have achieved the best results regarding reduction of substance use, promotion of abstinence, treatment attendance and retention in treatment. The first CM study conducted in Brazil advocates for the efficacy of CM on all of these outcomes, suggesting that CM can be effective in a Brazilian population of crack users.

Clinical Trial Description

The objective of this study is to evaluate the effectiveness of Contingency Management (CM) for crack users living in the "Crackland" region. To achieve this goal, regular treatment staff from Unidade Helvétia and CRATOD treatment services will be capacitated in CM to latter-on apply the CM intervention in their respective services. The design will be a crossover randomized clinical trial composed of a sample of 200 subjects with current diagnose for crack/cocaine dependence. Participants allocated to the control condition will receive 12 weeks of the usual care treatment provided by these two treatment facilities. Participants allocated to the experimental condition will receive the exact same treatment as control participants associated with CM. CM procedure will occur 2 timer per week (every Monday and Thursday or Tuesday and Friday). After 12 weeks of intervention, participants in the control condition (standard treatment alone) will receive 12 weeks of the experimental treatment (standard treatment plus CM) and participants in the experimental condition will receive 12 weeks of the control procedure. Primary outcomes are: (1)retention in treatment; (2) reduction of crack use; (3) promotion of continuous crack cocaine abstinence. Secondary findings are reduction on psychiatric symptomatology. The investigator hypothesis is that participants will have a better response in all studied outcomes when receiving treatment in the CM condition. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT03345394
Study type Interventional
Source Federal University of São Paulo
Contact André M de Queiroz Constantino Miguel, PhD
Phone 11965884111
Status Recruiting
Phase N/A
Start date December 1, 2017
Completion date September 1, 2020

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