Stroke Clinical Trial
Official title:
Stroke complicAtions After TraUmatic expeRieNces and Stress - a Retrospective Cohort Study
The primary aim of this retrospective cohort study is to test the hypothesis that previous traumatization (long) before an ischemic stroke increases the degree of stroke-induced PTSD symptoms at 9-13 months after the stroke event. Secondary outcome parameters include quality of life and depression.
Neuropsychiatric consequences of brain ischemia play a critical role in shaping long-term
stroke outcome. Unfortunately, however, as of now, clinical research and clinical practice
have not adequately addressed this growing challenge. A good case in point is posttraumatic
stress disorder (PTSD). Previous trauma exposure and posttraumatic stress symptoms may
increase the risk of cardiovascular events (Sumner et al., 2015). Moreover, unbeknownst to
most clinical neurologists, a significant portion (approximately 25%) of their stroke
patients develop symptoms of post-traumatic stress disorder (PTSD) within the first year
post-event. PTSD-related symptoms after an acute coronary syndrome increase the risk of
recurrent cardiac events and mortality (Edmondson et al., 2012). Similarly, stroke-induced
PTSD has been linked with worse long term stroke outcome, in particular, recurrent stroke,
greater disability, non-adherence to medications, and comorbidities (Goldfinger et al., 2014;
Kronish et al., 2012).
For a period of 22 months, all stroke patients treated at the Charité Medical Center will be
screened retrospectively 9-13 months after a first-ever ischemic stroke (~2000). All eligible
patients will be contacted by mail 9-13 months after their hospital stay with the request
that they complete the questionnaires. The mailing will also include an information
statement, the consent form, as well as a stamped return envelope.
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