Stroke Clinical Trial
Official title:
The Effect of the Self-empowered Upper Limb Repetitive Engagement (SURE) Program on Upper Limb Recovery Compared With Education in People With Stroke Undergoing Inpatient Rehabilitation
The aim of this study is to investigate the effect of SURE program on UL recovery during first few weeks post-stroke. A randomised blinded controlled pilot trial will be conducted. Twenty people with stroke will be randomly allocated to 4-weeks of SURE program or education program. This is to perform on top of their usual care. To determine the clinical benefit, all participants will be assessed pre-, 2 weeks during the training, post-training, 1-month and 3-month follow-up using a range of impairment and activity measures. To determine the cortical activation (fMRI), structural (FLAIR and DTI) and functional (resting state fcMRI) connectivity of cortical motor regions, all participants will undergo a 3T MRI pre-, post- and post-3 months after training.
Background:
UL recovery after stroke has been found to be limited. Efforts should be channelled into
rehabilitation to improve UL recovery after stroke. First 4-weeks post-stroke is the period
when neuroplasticity unfolds and when most rehabilitation occurs. This critical time window
should be capitalized to interact with spontaneous biological recovery to facilitate UL
recovery. There is growing evidence that shows that early increased UL practice after stroke
improves the recovery of upper limb function. However, it has also been found that the level
of early UL practice and use during early post-stroke is low. SURE program is a self-exercise
program which aims to empower people with stroke and their caregivers to increase early UL
practice outside therapy.
Aim:
To investigate the effect of SURE program on UL recovery during first few weeks post-stroke.
Method:
A randomised blinded controlled pilot trial will be conducted. Twenty people with stroke will
be randomly allocated to 4-weeks of SURE program or education program.
Intervention Group- SURE Program The intervention group will receive a SURE program booklet
and will perform individualized daily self-exercise and functional use of the arm and hand on
their own outside of therapy for 60 minutes/day, 6 days/week for 4 weeks. These
self-exercises and upper limb functional use will be performed in addition to usual care.
Three SURE program booklets have been developed which relate to the affected upper limb motor
capability using individual Fugl Meyer (ULFM) score. Each SURE program booklet consists of
warm-up exercises, strengthening exercises and motor tasks. The SURE program booklet also
includes selected functional motor tasks to be performed by the participants using their
affected upper limb. The performance of the exercises and functional motor tasks will be
reviewed three times per week for the first 2 weeks, two times for the third week and one
time for the fourth week of intervention period.
Control Group- Education The control group will receive an education booklet with 10 modules.
The education booklet will contain information on stroke, recovery and management strategies
after stroke. Participants are to complete 2-3 modules per week and answer 1-2 simple
questions after each module. Each module including answering questions takes approximately
5-10 minutes to complete. CPI will review the information with the participants 3 times per
week for the first 2 weeks, two times for the third week and one time for the fourth week of
intervention period.The participants in the control group will continue with their usual care
in the hospital.
To determine the clinical benefit, all participants will be assessed pre-, 2 weeks during the
training, post-training, 1-month and 3-month follow-up using a range of impairment and
activity measures. To determine the cortical activation (fMRI), structural (FLAIR and DTI)
and functional (resting state fcMRI) connectivity of cortical motor regions, all participants
will undergo a 3T MRI pre-, post- and post-3 months after training.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
Completed |
NCT04101695 -
Hemodynamic Response of Anodal Transcranial Direct Current Stimulation Over the Cerebellar Hemisphere in Healthy Subjects
|
N/A | |
Completed |
NCT04034069 -
Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
|
N/A | |
Suspended |
NCT03869138 -
Alternative Therapies for Improving Physical Function in Individuals With Stroke
|
N/A | |
Terminated |
NCT03052712 -
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
|
N/A | |
Completed |
NCT00391378 -
Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)
|
N/A | |
Recruiting |
NCT06204744 -
Home-based Arm and Hand Exercise Program for Stroke: A Multisite Trial
|
N/A | |
Active, not recruiting |
NCT06043167 -
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
|
||
Enrolling by invitation |
NCT04535479 -
Dry Needling for Spasticity in Stroke
|
N/A | |
Completed |
NCT03985761 -
Utilizing Gaming Mechanics to Optimize Telerehabilitation Adherence in Persons With Stroke
|
N/A | |
Recruiting |
NCT00859885 -
International PFO Consortium
|
N/A | |
Recruiting |
NCT06034119 -
Effects of Voluntary Adjustments During Walking in Participants Post-stroke
|
N/A | |
Completed |
NCT03622411 -
Tablet-based Aphasia Therapy in the Chronic Phase
|
N/A | |
Completed |
NCT01662960 -
Visual Feedback Therapy for Treating Individuals With Hemiparesis Following Stroke
|
N/A | |
Recruiting |
NCT05854485 -
Robot-Aided Assessment and Rehabilitation of Upper Extremity Function After Stroke
|
N/A | |
Active, not recruiting |
NCT05520528 -
Impact of Group Participation on Adults With Aphasia
|
N/A | |
Active, not recruiting |
NCT03366129 -
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
|
||
Completed |
NCT05805748 -
Serious Game Therapy in Neglect Patients
|
N/A | |
Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
|
||
Recruiting |
NCT05621980 -
Finger Movement Training After Stroke
|
N/A |