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NCT number NCT03300258
Study type Interventional
Source University of Wisconsin, Madison
Contact Peter G Adamczyk, Ph.D.
Phone 608-263-3231
Email peter.adamczyk@wisc.edu
Status Not yet recruiting
Phase N/A
Start date January 1, 2018
Completion date March 2022

Clinical Trial Summary

The aim of this Pilot study is to determine whether robotically targeted lower-limb pedaling therapy can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic resonance imaging (fMRI). Forty (40) adult stroke patients and 80 healthy controls will be enrolled in this study. Of the 40 patients, half will be randomly assigned to the robotically-targeted training ("robotic") group and will receive training on the targeted training task. The other half of the patients will perform a duration-matched aerobic pedaling exercise ("control" group). All stroke patients will be scanned before and after their training program while performing or imagining simple motor tasks. Behavioral assessments of motor and cognitive capacities will be collected at each timepoint. Healthy control subjects enrolled for device testing (20) will receive up to 5 training sessions in a modified robotic paradigm and 1 fMRI scan, in order to investigate motor learning and brain activity in a novel motor control task. Additional healthy pilot subjects (up to 60) will test training protocols and assessments during preparatory design phases of the project.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


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