Stroke Clinical Trial
Official title:
Based on the Method of Tract-based Spatial Statistics Investigated Scalp Acupuncture Combined Low-frequency Repetitive Transcranial Magnetic Stimulation on Brain White Matter Microstructure of Hemiplegic Patients With Stroke
To apply Bold-fMRI technology to observe and compare the differences of task-related activation of relevant brain cortex region in stroke hemiplegic patients and healthy subjects after finger grasping movement.
Stroke is one of the common cerebrovascular diseases. With the improvement of medical
conditions and treatment technology, the death rate of stroke patients has declined, but the
disability rate has increased. In China about 50%-70% of stroke patients have the residual
sequelae such as paralysis, paralalia dysfunction and so on.
Hemiplegic is the most frequent sequelae in post-stroke patients, finger movements recovery
has already became the most difficult question in all the movement kinematics and dynamics
rehabilitation,which affects the total movement function and ability of daily life in the
patients.The finger recovery is tightly related to the neural plastic and brain function
realignment.Furthermore, whether the special brain movement functional cortex area in
bilateral hemispheres can be effectively activated is the crucial solved link. A number of
recent literature have displayed the special brain motor area including the primary motor
cortex(M1), the supplementary motor area(SMA), the premotor area(PMA), the primary
sensorimotor area(SM1),the secondary area(SM2), the cingulate sulcus area(CMA) and the
cerebellum hemispheres(CB). However,the study on the above-mentioned motor area synchronously
activated when the patients after systematically rehabilitative treatment performed fingers
grasping task was reported rarely.
Bold-fMRI technology is a new brain functional imaging technology developed on the basis of
MRI in 1990s, which not only retains the anatomical imaging characteristics of ordinary MRI,
but also obtains the physiological information. The emergence of Bold-fMRI technology
provides a new way to study the mechanism, evaluation and prognosis of stroke rehabilitation,
and it shows a good research and clinical application value in the field of rehabilitation
medicine.
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