Clinical Trials Logo

Clinical Trial Summary

This research project will evaluate the relationship between cardiovascular risk factors, degrees of physical and mental activity prior to the stroke, brain tissue integrity, post-stroke community participation and neurological recovery after the stroke. Investigators will recruit and study healthy and post stroke participants, gaining insight into the possible mechanisms that explain why the adverse risk profile, which is more commonly present in African-Americans than non-Hispanic Whites in the stroke belt, is translated into a less favorable recovery post stroke.


Clinical Trial Description

Stroke is a common cause of disability, but not all subjects who survive a stroke are left with debilitating sequelae. The human brain is able to self-repair and adapt after injury through neuroplasticity, which is crucial for stroke recovery. At present, recovery cannot be completely predicted from clinical stroke variables. A promising theory suggests that the health status of the stroke host is as important as stroke severity for recovery. Within the neurological system, health is reflected by the integrity of the brain tissue and its neuronal environment, which provide the neuroplastic potential that is necessary for recovery. The potential for neuroplasticity is likely variable across individuals and possibly accounts for some of the differences in outcome that cannot be explained by other clinical factors. A better understanding of the relationship between stroke outcomes, host brain tissue integrity and recovery environment would have immense potential to address stroke related disabilities. The investigators are experts in research involving brain tissue integrity using neuroimaging and recovery environment using community based participation approaches involving nurse-guided community health workers (CHWs). This research project will evaluate the relationship between cardiovascular risk factors, degrees of physical and mental activity prior to the stroke, brain tissue integrity, post-stroke community participation and neurological recovery after the stroke. The investigators will recruit and study a biracial cohort, gaining insight into the possible mechanisms that explain why the adverse risk profile, which is more commonly present in African-Americans than non-Hispanic Whites in the stroke belt, is translated into a less favorable recovery post stroke. If a better understanding of the underlying reasons for this observation can be defined, an important first step toward eliminating this disparity can be achieved. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02982278
Study type Interventional
Source Medical University of South Carolina
Contact
Status Completed
Phase N/A
Start date October 2015
Completion date June 30, 2020

See also
  Status Clinical Trial Phase
Recruiting NCT05437406 - Family, Responsibility, Education, Support, and Health for Latino Caregivers (FRESH-LC) N/A
Completed NCT04100577 - Today Not Tomorrow Pregnancy and Infant Support Program (TNT- PISP) N/A
Recruiting NCT05041855 - Childhood Obesity Treatment Designed for Low Income and Hispanic Families N/A
Completed NCT02773069 - The Church as a Bridge to Deliver Health Resources Via Telehealth N/A
Enrolling by invitation NCT04508543 - Assessing Patient-provider Interactions During the Preoperative Anesthesia Consult
Completed NCT02507089 - Tailored Approach to Sleep Health Education: A Community Engaged Approach N/A
Terminated NCT03940300 - Farming for Life - Health Impact of Organic Vegetable Prescriptions for Adults Living With or at Risk of Type 2 Diabetes N/A
Withdrawn NCT05457530 - Doravirine and Weight Gain in Antiretroviral Naive Phase 3