Clinical Trials Logo
NCT number NCT03394950
Study type Interventional
Source General Hospital of Shenyang Military Region
Contact
Status Active, not recruiting
Phase Phase 4
Start date December 30, 2017
Completion date March 30, 2019

Clinical Trial Summary

Acute ischemic stroke (AIS) is the most common type of stroke, which has high rate of morbidity, mortality and disability. A large number of studies have confirmed that the thrombolytic therapy can effectively open blood vessels and improve the functional prognosis of acute ischemic stroke. Therefore, all guidelines recommend giving thrombolysis treatment to acute ischemic stroke patients within 4.5 hours of onset. However, about 1/3 patients receiving thrombolysis will have good prognosis, while a large number of patients will still be disabled and even dead. How to improve the neurofunctional prognosis of thrombolytic patients has been a hot topic in the world.

Butyl phthalide is type I chemical drugs. Some multicenter randomized, double-blind, placebo-controlled clinical trials have showed that acute ischemic stroke patients taking butyl phthalide has better lateral branch circulation and living ability score than patients taking placebo. Besides, butyl phthalide treatment is safe. The animal experiment indicated that buphthalein could significantly improve secondary side branch circulation, recover the microarterial diameter of the soft meninges in the ischemic region and increase the blood flow rate.

Based on the discussion, we assume that: giving butyl phthalide to patients with acute ischemic stroke in advance, might promote and improve the formation of collateral circulation to freeze ischemia penumbra. Based on this hypothesis, we would like to explore the efficacy and safety of butyl phthalide combined with rtPA thrombolysis in the treatment of acute ischemic stroke.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


See also
  Status Clinical Trial Phase
Completed NCT01937182 - The Efficacy of Citalopram Treatment in Acute Stroke Phase 2
Not yet recruiting NCT03211130 - Using SystemCHANGE™ to Enhance Medication Adherence in Older Adult Stroke Survivors Early Phase 1
Not yet recruiting NCT03243318 - Motor Evoked Potential in the Affected Upper Limb Predicts the Potential of Motor Recovery After Ischemic Stroke N/A
Recruiting NCT01716481 - The STem Cell Application Researches and Trials In NeuroloGy-2 (STARTING-2) Study Phase 3
Active, not recruiting NCT03038685 - A Personalized, Digital Coaching Program After Stroke N/A
Completed NCT03334968 - Prolidase Enzyme Activity in Stroke Patients N/A
Recruiting NCT03098732 - Magnetically Enhanced Diffusion for Acute Ischaemic Stroke (MEDIS) Trial N/A
Enrolling by invitation NCT03199404 - Trevo Aspiration Proximal Flow Control Registry N/A
Recruiting NCT03067818 - Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis N/A
Recruiting NCT03291392 - CUHK Stroke Biobank N/A
Recruiting NCT03177161 - Assessment of Patient Reported Health Status Questions Via Four Different Methods of Administration, in Stroke Survivors. N/A
Completed NCT03195907 - Pulmonary Physiotherapy for Ischemic Stroke N/A
Not yet recruiting NCT03355742 - XIENCE 28 Global Study N/A
Not yet recruiting NCT03360656 - Transnasal Induction of Normothermia in Febrile Stroke Patients N/A
Not yet recruiting NCT03344146 - Electronic Monitoring and Improvement of Adherence to DOACs in Polymedicated Stroke Patients N/A
Active, not recruiting NCT03320018 - Neuroprotection in Acute Ischemic Stroke Phase 2/Phase 3
Not yet recruiting NCT03160131 - Rehabilitation of Visual Function After Brain Injury N/A
Recruiting NCT03275155 - Pathophysiology and Risk of Atrial Fibrillation Detected After Ischemic Stroke N/A