Clinical Trials Logo

Clinical Trial Summary

Acute ischemic stroke (AIS) is the most common type of stroke, which has high rate of morbidity, mortality and disability. A large number of studies have confirmed that the thrombolytic therapy can effectively open blood vessels and improve the functional prognosis of acute ischemic stroke. Therefore, all guidelines recommend giving thrombolysis treatment to acute ischemic stroke patients within 4.5 hours of onset. However, about 1/3 patients receiving thrombolysis will have good prognosis, while a large number of patients will still be disabled and even dead. How to improve the neurofunctional prognosis of thrombolytic patients has been a hot topic in the world.

Butyl phthalide is type I chemical drugs. Some multicenter randomized, double-blind, placebo-controlled clinical trials have showed that acute ischemic stroke patients taking butyl phthalide has better lateral branch circulation and living ability score than patients taking placebo. Besides, butyl phthalide treatment is safe. The animal experiment indicated that buphthalein could significantly improve secondary side branch circulation, recover the microarterial diameter of the soft meninges in the ischemic region and increase the blood flow rate.

Based on the discussion, we assume that: giving butyl phthalide to patients with acute ischemic stroke in advance, might promote and improve the formation of collateral circulation to freeze ischemia penumbra. Based on this hypothesis, we would like to explore the efficacy and safety of butyl phthalide combined with rtPA thrombolysis in the treatment of acute ischemic stroke.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT03394950
Study type Interventional
Source General Hospital of Shenyang Military Region
Contact Xiao-wen Hou, Master
Phone 86 15840240196
Status Recruiting
Phase Phase 4
Start date May 25, 2018
Completion date March 30, 2019

See also
  Status Clinical Trial Phase
Recruiting NCT03558659 - Positional Therapy to Treat Obstructive Sleep Apnea in Stroke Patients N/A
Completed NCT01937182 - The Efficacy of Citalopram Treatment in Acute Stroke Phase 2
Recruiting NCT03649711 - Chronic Kidney Disease (CKD) Platelet Study Phase 3
Not yet recruiting NCT03648957 - Lifestyle Counselling as Secondary Prevention in Patients With Minor Stroke and Transient Ischemic Attack N/A
Not yet recruiting NCT03592563 - CUHK Brain Health Longitudinal Study
Recruiting NCT03552354 - Argatroban Combined With Antiplatelet Versus Antiplatelet for Acute Ischemic Stroke Phase 4
Not yet recruiting NCT03699397 - EEG Controlled Triage in the Ambulance for Acute Ischemic Stroke N/A
Not yet recruiting NCT03211130 - Using SystemCHANGE™ to Enhance Medication Adherence in Older Adult Stroke Survivors Early Phase 1
Not yet recruiting NCT03243318 - Motor Evoked Potential in the Affected Upper Limb Predicts the Potential of Motor Recovery After Ischemic Stroke N/A
Recruiting NCT01716481 - The STem Cell Application Researches and Trials In NeuroloGy-2 (STARTING-2) Study Phase 3
Recruiting NCT03621917 - Evaluation of tPA Efficacy in Acute Stroke Patients With NIRS (Near-infrared Spectroscopy)
Completed NCT03507517 - Quality Control Project of Stroke in Liaoning Province
Active, not recruiting NCT03038685 - A Personalized, Digital Coaching Program After Stroke N/A
Completed NCT03334968 - Prolidase Enzyme Activity in Stroke Patients N/A
Recruiting NCT03098732 - Magnetically Enhanced Diffusion for Acute Ischaemic Stroke (MEDIS) Trial N/A
Not yet recruiting NCT03443245 - Differential Metabolic Signature of Stroke Patients Undergoing Thrombolysis N/A
Recruiting NCT03485040 - Stroke Motor Rehabilitation and Recovery Study
Enrolling by invitation NCT03199404 - Trevo Aspiration Proximal Flow Control Registry
Recruiting NCT03067818 - Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis N/A
Recruiting NCT03291392 - CUHK Stroke Biobank