Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne

STAPHYLOCOCCAL INFECTIONS Clinical Trial

— ColoStaph  

Official title:

Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02502474
• Other study ID #: 1408023
• Secondary ID: 2014-A00755-42
• Status: Completed
• Phase: N/A
• Start date: February 2, 2015
• Est. completion date: October 20, 2017

Study information

• Verified date: September 2018
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Epidemiological study aiming to describe the carriage (nasal, throat, groin, rectal and colonic) of S. aureus in patients without chronic digestive disease who are going to have a colonoscopy for cancer screening. The carriage will be analyzed globally and the similarity of strains isolated from each site will be analyzed using molecular tools. The aim of this study is to better estimate the digestive reservoir of S. aureus to better prevent endogenous infections due to this bacterium.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 112
• Est. completion date: October 20, 2017
• Est. primary completion date: October 20, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Patient affiliated to French social security

• Written consent of the patient

• Patient needing a colonoscopy in the University Hospital of Saint-Etienne, France

Exclusion Criteria:

• Patient who decline to participate to the study

• Patient in the incapacity to give consent

• Patient receiving treatment with anticoagulant or antiaggregant platelets

• Patients with a known haemostatic disorder

• Pregnant woman

• Patients with a chronic disease of the gastrointestinal tract

• Patients receiving long-term corticosteroid

• Patient receiving anti staphylococcal antibiotics

Related Conditions & MeSH terms

• STAPHYLOCOCCAL INFECTIONS

Intervention

Other:
• Staphylococcus aureus carriage
nasal, throat, rectal and groin sampling with swabs. Colonic sampling by colonic biopsy

Locations

Country	Name	City	State
France	CHU Saint-Etienne	Saint-Etienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of patient with Staphylococcus aureus colonic carriage	Staphylococcus aureus carriage in the colon is measured by biopsy	Day 1
Secondary	Number of patient with similar Staphylococcus aureus strains in the nose and in the rectum	Staphylococcus aureus carriage in the rectum and in the nose is measured by swab culture	Day 1
Secondary	Number of patient with Staphylococcus aureus carriage in the nose	Staphylococcus aureus carriage in the nose is measured by swab culture.	Day 1
Secondary	Number of patient with Staphylococcus aureus carriage in the throat	Staphylococcus aureus carriage in the throat is measured by swab culture.	Day 1
Secondary	Number of patient with Staphylococcus aureus carriage in the groin	Staphylococcus aureus carriage in the groin is measured by swab culture.	Day 1