Spinal Surgery Clinical Trial
Official title:
Evaluation of the Prevalence of Germs Slow Growth in the Intervertebral Disc (IVD) During Spinal Surgery: a Single-center Prospective Observational Study
Low back pain is one of the most frequent reasons for consultation in rheumatology. There is
a strong correlation between low back pain, and the presence of a type of Modic 1 signal on
MRI.
The anomaly Modic 1 results in a hypointense signal T1-weighted images and hyperintense on
T2-weighted sequences (including T2 STIR and / or Fat Sat) and contrast enhancement of the
endplates after gadolinium injection; it corresponds to a replacement of normal cancellous
bone of fibrovascular tissue.
The origin of this inflammatory process Modic 1 into the vertebra is still unknown.
infectious hypothesis was raised, including contamination by germs called "slow-growth" such
as Propionibacterium acnes (PA).
Many studies interesting Bacteriological analysis of disc material found the presence of
bacteria (prevalence between 0 and 54%).
A recent clinical trial evaluating the efficacy of antibiotic treatment compared to placebo
in low back pain with Modic 1; a show effectiveness of this treatment on the different
clinical parameters evaluated.
However skin contamination is not formally excluded, particularly in patients previously
infiltrated (including epidural).
Our hypothesis is that the slow-growing bacteria are not involved in Modic 1 type of disc
disease, and the possible presence of PA or other slow-growing bacteria in samples obtained
discal posterior approach would be related to intraoperative contamination or during
preoperative spinal infiltrations The main objective is to assess the prevalence of germs
slow growth in the intervertebral disc in the spinal surgery by anterior disc disease in
type 1 Modic.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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