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Study of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Mesothelin-directed CAR-T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.

Solid Tumor, Adult Clinical Trial

Official title:
Phase I Study to Evaluate Treatment of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Chimeric Antigen Receptor (CAR) T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.

Clinical Trial Summary

Multiple solid tumors have positive targets of mesothelin expressed on the surfaces of the tumor cells, we use the technique of CRISPR-Cas9 to knocked out the PD-1 and TCR of chimeric antigen receptor (CAR) T cells to effect the immuno-microenvironment around tumors.

Clinical Trial Description

1. To evaluate the feasibility and safety of CRISPR-Cas9 mediated PD-1 and TCR gene-knocked out chimeric antigen receptor (CAR) T cells in patients with mesothelin positive multiple solid tumors.

2. To evaluate the duration of in vivo persistence of transferred CAR-T cells.

3. To observe and measure anti-tumor responses for patients with detectable mesothelin positive tumor lesions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03545815
Study type Interventional
Source Chinese PLA General Hospital
Contact Wweidong Han, Dr.
Phone 86-10-13651392893
Email hanwdrsw@sina.com
Status Recruiting
Phase Phase 1
Start date March 19, 2018
Completion date December 30, 2020
View Details
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