Olfactory Decision-making and Deprived Sleep

Sleep Deprivation Clinical Trial

— ODDS  

Official title:

Olfactory Decision-making and Deprived Sleep

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05093413
• Other study ID #: STU00215342
• Status: Completed
• Phase: N/A
• Start date: January 14, 2021
• Est. completion date: May 19, 2022

Study information

• Verified date: July 2022
• Source: Northwestern University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: May 19, 2022
• Est. primary completion date: May 19, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• At least 18 years old

• Fluent English speakers

Exclusion Criteria:

• History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)

• History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)

• Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)

• Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)

• Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)

• Smell or taste dysfunction

• History of severe allergies requiring hospitalization for treatment

• History of severe asthma requiring hospitalization for treatment

• Habitual smoking

• History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)

• Dieting or fasting

• History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)

• Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)

• History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers

• Left-handedness

• Claustrophobia

Related Conditions & MeSH terms

• Sleep Deprivation

Intervention

Behavioral:
• Sleep deprivation
Fully slept: Sleep habitual amount (i.e., go to sleep at habitual bedtime and wake up at habitual wake time) Sleep deprived: Reduce sleep by 50% (i.e., go to sleep at habitual bedtime and wake up early)

Locations

Country	Name	City	State
United States	Northwestern University	Chicago	Illinois

Sponsors (1)

Lead Sponsor	Collaborator
Northwestern University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Behavior an olfactory perceptual decision-making task	Food-like perceptual responses to binary food-nonfood odor mixtures	Up to 24 hours after the intervention
Secondary	Resting-state functional magnetic resonance imaging	Resting-state activity determined by functional magnetic resonance imaging	Up to 24 hours after the intervention