Serum Magnesium Level Administration in Severe Pre-eclampsia Obese Pregnancy

Severe Pre-eclampsia Clinical Trial

Official title: Serum Magnesium Level Between Administered Rate of 2 g/hr Versus 2.5 g/hr in Severe Pre-eclampsia Obese Pregnancy, Multicentered Randomized Study

Status Completed

Clinical Trial Summary

Comparison of the magnesium level in difference continuous rate in women who were diagnosed severe pre-eclampsia obese

Clinical Trial Description

Magnesium sulfate is, generally, applied in order to alleviate or to avoid seizures. It can be administered according to many medical approaches. Nevertheless, at Rajavithi Hospital, the recommended administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour (Zudpan regimen). The therapeutic index of magnesium is in the range of 4.8-8.4 mg/dL. After that, the level of magnesium sulfate will be evaluated every 4 or 6 hours.

At Rajavithi Hospital, there are a lot of patients having pre-eclampsia symptom and many patients, who were received magnesium sulfate in the treatment, having the level of magnesium sulfate lower than the therapuetic level and needed to increase the maintenance dose to 2.5 grams/hour. Therefore, this work aims to studying the amount of magnesium sulfate administered to pregnant woman with pre-eclampsia symptom who possess high body mass index (BMI), especially for BMI greater than or equal to 30 kg/m2. ;

Related Conditions & MeSH terms

• Eclampsia
• Magnesium Level
• Pre-Eclampsia
• Severe Pre-eclampsia

• NCT number: NCT03661775
• Study type: Interventional
• Source: Rajavithi Hospital
• Status: Completed
• Phase: N/A
• Start date: September 30, 2018
• Completion date: May 31, 2019