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Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock

Septic Shock Clinical Trial

Official title:
Initiation of Vitamin C, Thiamine and Hydrocortisone Therapy for Septic Shock in Adults: A Randomized Clinical Trial

Clinical Trial Summary

The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.

Clinical Trial Description

Septic Shock is a leading cause of morbidity and mortality in critically ill patients worldwide. A potential benefit of vitamin C with thiamine and low-dose hydrocortisone in the treatment of septic shock has recently been described(PMID 27940189) . The patients with septic shock who received this combination of medications weaned off pressors earlier, suffered less organ failure, and had improved mortality. The doses of vitamin C used in this trial are high, yet seemed to be safe and can be considered for use. In this randomized controlled trial, we aim to evaluate the effect of the combination therapy (vitamin C,thiamine and hydrocortisone) on septic shock. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03872011
Study type Interventional
Source Northern Jiangsu Province People's Hospital
Contact
Status Completed
Phase Phase 3
Start date February 19, 2019
Completion date September 20, 2021
View Details
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