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NCT01877798 Clinical Trial

Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy

Septic Shock Clinical Trial

Official title:
Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Severe Sepsis and Septic Shock Therapy

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT01877798
Other study ID # PCSS
Secondary ID
Status Not yet recruiting
Phase N/A
First received June 12, 2013
Last updated June 13, 2013
Start date June 2013

Study information
Verified date June 2013
Source Peking Union Medical College Hospital
Contact n/a
Is FDA regulated No
Health authority China: Ministry of Health
Study type Interventional

Clinical Trial Summary

Reducing tissue hypoxia is the ultimate goal of severe sepsis and septic shock therapy.Venoarterial PCO2 difference /arteriovenous O2 content difference ratio (△PCO2/Ca-vO2) is considered to be a good indicator of global anaerobic metabolism.The purpose of this study was to compare the efficacy of △PCO2/Ca-vO2 and central venous oxygen saturation (ScvO2) in the treatment of severe sepsis and septic shock.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 300
Est. completion date
Est. primary completion date June 2016
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- severe sepsis and septic shock patients

Exclusion Criteria:

- <18 years old

- pregnant and breast-feed woman

- AMI

- cerebral hemorrhage

- contraindication for central venous catheter or arterial catheter;

- brainstem death

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Procedure:
• volume resuscitation, vasoactive drug

Locations
Country Name City State
China Peking Union Medical College Hospital critical care medicine Beijing

Sponsors (1)
Lead Sponsor Collaborator
Peking Union Medical College Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary mortality 30 days Yes
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