Sepsis Clinical Trial
Official title:
Neutrophil-lymphocyte Ratio Versus Lactate-albumin Ratio as a Predictor of Morbidity and Mortality in Patients With Sepsis and Septic Shock
The aim of the study is to compare between neutrophil lymphocyte ratio and lactate albumin ratio as a predictor of morbidity and mortality in sepsis and septic shock patients.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | October 2023 |
Est. primary completion date | September 2023 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria - Age from 18 to 60 years old. - Patients with suspected infection who fulfilled at least two of three quick sepsis - related organ failure assessment (QSOFA) criteria - Patients with Organ dysfunction can be confirmed by acute change in SOFA score variables >2 points consequent to infection. - Sepsis with persisting hypotension requiring vasopressors to maintain MAP > 65 mm Hg and having a serum lactate level > 2mmol/L despite adequate volume of resuscitation. Exclusion criteria - No informed consent. - Malignancy and chemotherapy during the previous 90 days. - History of steroid therapy within 3 months before admission. - Patients with either established hepatic dysfunction, renal failure, having any disease in which albumin should be supplemented as liver cirrhosis with ascites, nephrotic syndrome and burn. |
Country | Name | City | State |
---|---|---|---|
Egypt | Tanta U | Tanta |
Lead Sponsor | Collaborator |
---|---|
Tanta University |
Egypt,
Cao C, Yu M, Chai Y. Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis. Cell Death Dis. 2019 Oct 14;10(10):782. doi: 10.1038/s41419-019-2015-1. — View Citation
Fortini A, Faraone A, Meini S, Bettucchi M, Longo B, Valoriani B, Forni S; Italian Federation of Hospital Internists (FADOI) - Sepsis Collaboration Group of the Tuscany Region. Validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in Internal Medicine wards; a prospective, multicenter study. Eur J Intern Med. 2021 Mar;85:92-97. doi: 10.1016/j.ejim.2020.12.025. Epub 2021 Jan 12. — View Citation
Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013 May;41(5):1167-74. doi: 10.1097/CCM.0b013e31827c09f8. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prediction of 28 day mortality. | Prediction of 28 day mortality (patients will be followed by telephone for 28 day after discharge). | 28 days | |
Secondary | Extent of organ dysfunction in patients with sepsis and septic shock assessed by SOFA score | SOFA score for assessment of organ dysfunction in 0 hours, 6 hours, 24 hours of admission to icu. | 0 hours, 6 hours, 24 hours of admission to icu |
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