Sepsis Clinical Trial - Cefiderocol PK in Patients on ECMO

Status Recruiting

Clinical Trial Summary

Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary life-support for critically ill patients where blood is extracted from the vascular system and circulated by a mechanical pump while it is oxygenated and reinfused into the patient's circulation. It is well known that critically ill patients may experience alterations in antibiotic pharmacokinetics, and as a result, dosing modifications are generally required. There is a need to understand how ECMO circuits affect the pharmacokinetics and disposition of drugs. This study is designed to assess the pharmacokinetics of the new broad-spectrum antibiotic, Cefiderocol, in critically ill patient receiving ECMO.

Clinical Trial Description

This is a prospective, open-label, Phase 1b, pharmacokinetic study of Cefiderocol in 8 critically ill patients receiving ECMO support at Hartford Hospital. Informed consent will be collected from all study participants, legal authorized representative, or their next of kin in order to participate. This is not a treatment study; all participants will receive other antibiotics as necessary to treat any current infection. ;

Study Design

Related Conditions & MeSH terms

Sepsis

Clinical Trial Details

NCT number	NCT04995835
Study type	Interventional
Source	Hartford Hospital
Contact	Joseph L Kuti, PharmD
Phone	8609723612
Email	joseph.kuti@hhchealth.org
Status	Recruiting
Phase	Phase 1
Start date	July 16, 2021
Completion date	July 16, 2024

View Details

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