Sepsis Clinical Trial
Official title:
Prospective Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis- Experience From a Tertiary Care Hospital in Pakistan
Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein. Investigators propose that adding Procalcitonin to the list of standard laboratory work up of critically ill patients with suspected sepsis could increase diagnostic accuracy leading to better patient care.
Background: Sepsis is the leading cause of mortality in critically ill patients.
Procalcitonin (PCT) is a promising marker for identification of bacterial sepsis. The aim of
this study was to determine the diagnostic accuracy of serum PCT concentration in patients
with suspected sepsis admitted to mixed medical-surgical Intensive care unit (ICU).
Material and Methods: A cross-sectional study conducted at section of Chemical Pathology,
Department of Pathology and Laboratory Medicine and ICU. Patients with suspected sepsis were
included, serum PCT cut off ≥0.5 ng /ml was taken for diagnosing sepsis. Diagnostic accuracy
was measured in terms of sensitivity, specificity, positive predictive value (PPV) and
negative predictive value (NPV) taking blood culture as gold standard. Furthermore, different
cut offs were compared by using receiver operating characteristic curves (ROC). Data analysis
was done on SPSS version.
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