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NCT03497741 Clinical Trial

Predictive Value of Procalcitonin for Bacteremia in the ICU

Sepsis Clinical Trial

Official title:
Predictive Value of Procalcitonin for Bacteremia in the ICU

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03497741
Other study ID # 2016-0877
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date October 1, 2017
Est. completion date April 1, 2019

Study information
Verified date October 2018
Source Rijnstate Hospital
Contact D Hoogeveen
Phone 088 005 3692
Email DHoogeveen@rijnstate.nl
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Association between plasma procalcitonin levels and positive blood cultures in critical illness patients in the ICU.

Description:

Rationale: Association of procalcitonin levels and blood cultures in critical illness patients on the ICU.

Objective: Procalcitonin is an acute phase protein. As part of the acute phase response, procalcitonin is produced during sepsis. Previous research shows that procalcitonin is a biomarker for bloodstream infection. However, there is still little known about the value of procalcitonin in diagnostics for micro-organism underlying a sepsis in ICU patients. In modern practice, blood cultures are taken when a patient is septic to determine the responsible micro-organism. When procalcitonin is a predictive value for bacteremia in the ICU, the number of blood cultures can be reduced.

Study design: An observational cohort study intervention: for each patient in the ICU blood cultures were taken, the procalcitonin level was determined. During 6 months 150 patients will be included.

Main study parameters/endpoints: this study will examine the predictive value of procalcitonin in blood cultures on the ICU.

Recruitment information / eligibility
Status Recruiting
Enrollment 150
Est. completion date April 1, 2019
Est. primary completion date April 1, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients admitted to the ICU

- Age > 18 years

Exclusion Criteria:

- Hemodialysis/ Continuous Veno-Venous Hemofiltration

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• procalcitonin measurement
For each patient were blood cultures were taken, a procalcitonin level was determined

Locations
Country Name City State
Netherlands Rijnstate hospital Arnhem Gelderland

Sponsors (1)
Lead Sponsor Collaborator
Rijnstate Hospital

Country where clinical trial is conducted

Netherlands, 

Outcome
Type Measure Description Time frame Safety issue
Primary The predictive value of procalcitonin in blood cultures on the ICU This study will examine the predictive value of procalcitonin on blood cultures on the ICU. A high value of procalcitonin is a predictor for bacteremia.
The predictive value: procalcitonin. Primary outcome: bacteremia .		 6 months
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