Low Intensity 'Blue Light' Treatment of Seasonal Affective Disorder

Status Completed

Clinical Trial Summary

One of the most frequently investigated hypothesis of the pathophysiology underlying Seasonal Affective Disorder(SAD) or so called winter depression is a disturbance of circadian rhythms. Since the circadian system is especially sensitive for the blue portion of the light spectrum, a new light therapy device with more blue light (blue enriched polychromatic light) was tested for its efficacy to treat SAD. In chronobiological terms this light is hypothesized to be more potent in inducing non-visual effects. In the present study fluorescent tubes that emit a high portion of short wavelength light on top of the normal wavelengths are tested for its superiority in treating SAD. This blue-enriched light (colour temperature 17000 ºK) is compared to standard light treatment (5000 º K) in SAD patients.,In a earlier study it was shown that the therapeutic effect of blue enriched light were equal to standard light treatment using light in both conditions with an intensity of 10 000 lux. In the present study, blue enriched light with an intensity of 750 lux was used, because of the possible saturation effect in the former study. The investigators hypothesise that blue- enriched light with a low intensity improve the therapeutic effects of light treatment leading to a higher response or the same response in a shorter time schedule compared to standard light treatment.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01149135
Study type	Interventional
Source	University Medical Center Groningen
Contact
Status	Completed
Phase	N/A
Start date	October 2008
Completion date	March 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00502320` - Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder	Phase 4
Completed	`NCT00046241` - Prevention of Seasonal Affective Disorder	Phase 3
Completed	`NCT00006517` - Clinical Trials of Three Non-Drug Treatments for Winter Depression (SAD)	N/A
Active, not recruiting	`NCT03691792` - Optimizing Long-Term Outcomes for Winter Depression With CBT-SAD and Light Therapy	N/A
Completed	`NCT01462058` - The Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff	Phase 4
Recruiting	`NCT01030276` - Bright Light Therapy in Seasonal Affective Disorder (SAD)	N/A
Completed	`NCT01292889` - Study of Genes in Relation to Seasonal Affective Disorder and Major Depressive Disorder	N/A
Completed	`NCT01048294` - Blue Enriched Versus Standard Light Treatment for Seasonal Affective Disorder(SAD)	N/A
Completed	`NCT02582398` - Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET	N/A
Completed	`NCT01293409` - Bright Light Therapy in Seasonal Affective Disorder (SAD)	N/A
Active, not recruiting	`NCT00269633` - Research Study of Treatment for Winter Depression With Different Colors of Light	Phase 2
Completed	`NCT00076245` - Cognitive Behavioral Therapy for the Treatment of Seasonal Affective Disorder (SAD)	Phase 1
Completed	`NCT03313674` - Investigation of Seasonal Variations of Brain Structure and Connectivity in SAD	N/A
Completed	`NCT00016666` - Clinical Trial of Propranolol for Seasonal Affective Disorder	Phase 2
Recruiting	`NCT00114322` - Light-Emitting Diode (LED) Light for Seasonal Affective Disorder (SAD) Treatment	N/A
Completed	`NCT00001485` - Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder	N/A
Completed	`NCT01462305` - 30-Minute Light Exposure for the Treatment of Seasonal Affective Disorder	N/A
Completed	`NCT00139997` - Environmental Treatment for Seasonal Affective Disorder (SAD)	N/A
Completed	`NCT04251000` - Infrared Photomodulation Therapy for Seasonal Affective Disorder	N/A
Completed	`NCT00809523` - A Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)	Phase 2/Phase 3